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Ephrin receptor

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{{STRUCTURE_3fxx| PDB=3fxx | SIZE=300| SCENE= |right|CAPTION=Human ephrin A3 receptor (grey) complex with peptide substrate (green), nucleotide derivative (stick model) and Mg+2 ion [[3fxx]] }}
{{STRUCTURE_3fxx| PDB=3fxx | SIZE=300| SCENE= |right|CAPTION=Human ephrin A3 receptor (grey) complex with peptide substrate (green), nucleotide derivative (stick model) and Mg+2 ion [[3fxx]] }}
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'''Ephrin receptors''' (EPH) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPH contains a sterile-α-motif (SAM) domain and a second fibronectin III domain (fn3). For more details see [[ Ephrin Type-A Receptor]].
+
'''Ephrin receptors''' (EPHR) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPHR domains include an ectodomain (residues 23-435) containing the LBD (residues 23-326), a second fibronectin III domain (fn3) (residues 446-539), a transmembrane domain (residues 539-563), a kinase domain (residues 596-900) and a sterile-α-motif (SAM) domain (residues 908-972). For more details see [[ Ephrin Type-A Receptor]].
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*Ephrin A1 receptor
*Ephrin A1 receptor
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**[[3kka]] - hEPH A1 SAM+ hEPH A2 SAM – human<BR />
+
**[[3kka]] - hEPHR A1 SAM+ hEPH A2 SAM – human<BR />
-
**[[3hil]] - hEPH A1 SAM<br />
+
**[[3hil]] - hEPHR A1 SAM<br />
-
**[[2k1l]] - hEPH A1 transmembrane domain – NMR<BR />
+
**[[2k1l]] - hEPHR A1 transmembrane domain – NMR<BR />
-
**[[1x5a]] - hEPH A1 fn3 domain – NMR<BR />
+
**[[1x5a]] - hEPHR A1 fn3 domain – NMR<BR />
*Ephrin A2 receptor
*Ephrin A2 receptor
-
**[[3hpn]], [[3c8x]] - hEPH A2 LBD<BR />
+
**[[3hpn]], [[3c8x]] - hEPHR A2 LBD<BR />
-
**[[2x10]], [[3fl7]] - hEPH A2 ectodomain<BR />
+
**[[2x10]], [[3fl7]] - hEPHR A2 ectodomain<BR />
-
**[[2k9y]], [[2e8n]] - hEPH A2 transmembrane domain – NMR<BR />
+
**[[2k9y]], [[2e8n]] - hEPHR A2 transmembrane domain – NMR<BR />
-
**[[1mqb]] - hEPH A2 kinase domain<BR />
+
**[[1mqb]], [[4p2k]], [[4pdo]], [[4trl]] - hEPHR A2 kinase domain<BR />
*''Ephrin A2 receptor binary complex''<br />
*''Ephrin A2 receptor binary complex''<br />
-
**[[3mx0]], [[2x11]] - hEPH A2 ectodomain + ephrin A5<BR />
+
**[[3mx0]], [[2x11]] - hEPHR A2 ectodomain + ephrin A5<BR />
-
**[[3hei]], [[3czu]] - hEPH A2 LBD + ephrin A1<BR />
+
**[[3hei]], [[3czu]] - hEPHR A2 LBD + ephrin A1<BR />
-
**[[3mbw]] - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1<br />
+
**[[3mbw]] - hEPHR A2 LBD + carbohydrate-recognition domain + ephrin A1<br />
-
**[[2kso]] - hEPH A2 SAM + SHIP2<br />
+
**[[2kso]] - hEPHR A2 SAM + SHIP2<br />
*Ephrin A3 receptor
*Ephrin A3 receptor
-
**[[2qo2]], [[2qob]], [[2gsf]] - hEPH A3 kinase domain<BR />
+
**[[2qo2]], [[2qob]], [[2gsf]] - hEPHR A3 kinase domain<BR />
-
**[[2qok]], [[2qol]], [[2qon]], [[2qoo]], [[2qod]], [[2qof]], [[2qoi]] - hEPH A3 kinase domain (mutant) <BR />
+
**[[2qok]], [[2qol]], [[2qon]], [[2qoo]], [[2qod]], [[2qof]], [[2qoi]] - hEPHR A3 kinase domain (mutant) <BR />
-
**[[3fxx]], [[3fy2]] – hEPH A3 kinase domain + peptide substrate<BR />
+
**[[3fxx]], [[3fy2]] – hEPHR A3 kinase domain + peptide substrate<BR />
-
**[[2qoq]], [[2qo7]], [[2qo9]], [[2qoc]] - hEPH A3 kinase domain + AMP-PNP<BR />
+
**[[2qoq]], [[2qo7]], [[2qo9]], [[2qoc]] - hEPHR A3 kinase domain + AMP-PNP<BR />
-
**[[3dzq]] - hEPH A3 kinase domain + inhibitor<br />
+
**[[3dzq]], [[4gk2]], [[4gk3]], [[4gk4]], [[4p5q]], [[4p5z]] - hEPHR A3 kinase domain + inhibitor<br />
-
**[[4g2f]] - hEPH A3 kinase domain (mutant) + inhibitor<br />
+
**[[4g2f]] - hEPHR A3 kinase domain (mutant) + inhibitor<br />
*Ephrin A4 receptor
*Ephrin A4 receptor
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**[[2wo1]], [[3ckh]] - hEPH A4 LBD<BR />
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**[[2wo1]], [[3ckh]] - hEPHR A4 LBD<BR />
-
**[[4bk4]], [[4m4p]] - hEPH A4 ectodomain<br />
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**[[4bk4]], [[4m4p]] - hEPHR A4 ectodomain<br />
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**[[2lw8]] - hEPH A4 LBD – NMR<br />
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**[[2lw8]] - hEPHR A4 LBD – NMR<br />
-
**[[2hel]] – mEPH A4 membrane and kinase domains – mouse<br />
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**[[2hel]] – mEPHR A4 membrane and kinase domains – mouse<br />
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**[[2y6m]] – mEPH A4 kinase domain<br />
+
**[[2y6m]] – mEPHR A4 kinase domain<br />
*''Ephrin A4 receptor binary complex''<br />
*''Ephrin A4 receptor binary complex''<br />
-
**[[2wo3]] - hEPH A4 LBD + ephrin A2 receptor-binding domain<BR />
+
**[[2wo3]] - hEPHR A4 LBD + ephrin A2 receptor-binding domain<BR />
-
**[[2wo2]], [[3gxu]] - hEPH A4 LBD + ephrin B2 receptor-binding domain<br />
+
**[[4w4z]], [[4w50]] - hEPHR A4 LBD (mutant) + peptide<br />
-
**[[4bk5]], [[4bka]], [[4m4r]] - hEPH A4 ectodomain + ephrin A5 LBD<br />
+
**[[2wo2]], [[3gxu]] - hEPHR A4 LBD + ephrin B2 receptor-binding domain<br />
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**[[4bkf]] - hEPH A4 ectodomain + ephrin B3 LBD<br />
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**[[4bk5]], [[4bka]], [[4m4r]] - hEPHR A4 ectodomain + ephrin A5 LBD<br />
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**[[2xyu]] – mEPH A4 kinase domain + inhibitor<br />
+
**[[4bkf]] - hEPHR A4 ectodomain + ephrin B3 LBD<br />
-
**[[2y6o]] – mEPH A4 kinase domain + cancer drug<br />
+
**[[2xyu]] – mEPHR A4 kinase domain + inhibitor<br />
 +
**[[2y6o]] – mEPHR A4 kinase domain + cancer drug<br />
*Ephrin A5 receptor
*Ephrin A5 receptor
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**[[2r2p]] - hEPH A5 kinase domain<BR />
+
**[[2r2p]] - hEPHR A5 kinase domain<BR />
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**[[1shx]] - mEPH A5 <br />
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**[[1shx]] - mEPHR A5 <br />
-
**[[4et7]] – hEPH A5 (mutant)<br />
+
**[[4et7]] – hEPHR A5 (mutant)<br />
*Ephrin A7 receptor
*Ephrin A7 receptor
-
**[[3nru]] – hEPH A7 LBD<BR />
+
**[[3nru]] – hEPHR A7 LBD<BR />
-
**[[3h8m]] – hEPH A7 SAM<BR />
+
**[[3h8m]] – hEPHR A7 SAM<BR />
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**[[2rei]] - hEPH A7 kinase domain<BR />
+
**[[2rei]] - hEPHR A7 kinase domain<BR />
-
**[[3dko]] – hEPH A7 kinase domain + inhibitor
+
**[[3dko]] – hEPHR A7 kinase domain + inhibitor
*Ephrin A8 receptor
*Ephrin A8 receptor
-
**[[3kul]] - hEPH A8 kinase domain<BR />
+
**[[3kul]] - hEPHR A8 kinase domain<BR />
-
**[[1x5l]] – hEPH A8 fn3 domain – NMR<BR />
+
**[[1x5l]] – hEPHR A8 fn3 domain – NMR<BR />
-
**[[1ucv]] - hEPH A8 SAM – NMR<BR />
+
**[[1ucv]] - hEPHR A8 SAM – NMR<BR />
*Ephrin B1 receptor
*Ephrin B1 receptor
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**[[2eao]] – hEPH B1 SAM – NMR<BR />
+
**[[2eao]] – hEPHR B1 SAM – NMR<BR />
-
**[[2djs]] - hEPH B1 fn3 domain – NMR<BR />
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**[[2djs]] - hEPHR B1 fn3 domain – NMR<BR />
-
**[[3zfx]] - hEPH B1 kinase domain<br />
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**[[3zfx]] - hEPHR B1 kinase domain<br />
*Ephrin B2 receptor
*Ephrin B2 receptor
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**[[3etp]] – hEPH B2<BR />
+
**[[3etp]] – hEPHR B2<BR />
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**[[1f0m]] – mEPH B2 SAM<BR />
+
**[[1b4f]] - hEPHR B2 SAM<br />
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**[[1iko]] - mEPH B2 ectodomain<br />
+
**[[1f0m]] – mEPHR B2 SAM<BR />
-
**[[2i85]] - hEPH B2 ectodomain<br />
+
**[[1iko]] - mEPHR B2 ectodomain<br />
-
**[[1sgg]] - mEPH B2 SAM – chicken - NMR<BR />
+
**[[2i85]] - hEPHR B2 ectodomain<br />
 +
**[[1sgg]] - mEPHR B2 SAM – chicken - NMR<BR />
*''Ephrin B2 receptor binary complex''<br />
*''Ephrin B2 receptor binary complex''<br />
-
**[[2vsk]], [[2vsm]] – hEPH B2 + Viral Hemagglutinin-neuraminidase<BR />
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**[[2vsk]], [[2vsm]] – hEPHR B2 + Viral Hemagglutinin-neuraminidase<BR />
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**[[2qbx]] – hEPH B2 + peptide agonist<BR />
+
**[[2qbx]] – hEPHR B2 + peptide agonist<BR />
-
**[[2hen]] - hEPH B2 kinase domain + ADP<BR />
+
**[[2hen]] - hEPHR B2 kinase domain + ADP<BR />
-
**[[1shw]] - mEPH B2 LBD + ephrin A5<BR />
+
**[[1shw]] - mEPHR B2 LBD + ephrin A5<BR />
-
**[[1kgy]] - mEPH B2 LBD + ephrin B2 extracellular domain<BR />
+
**[[1kgy]] - mEPHR B2 LBD + ephrin B2 extracellular domain<BR />
*Ephrin B3 receptor
*Ephrin B3 receptor
-
**[[3p1i]] – hEPH B3 LBD<BR />
+
**[[3p1i]] – hEPHR B3 LBD<BR />
-
**[[3zfy]] - hEPH B3 kinase domain<br />
+
**[[3zfy]] - hEPHR B3 kinase domain<br />
*Ephrin B4 receptor
*Ephrin B4 receptor
-
**[[2qkq]] – hEPH B4 SAM<BR />
+
**[[2qkq]] – hEPHR B4 SAM<BR />
-
**[[2e7h]] – hEPH B4 fn3 domain - NMR<BR />
+
**[[2e7h]] – hEPHR B4 fn3 domain - NMR<BR />
-
**[[2x9f]], [[2vwy]] - hEPH B4 kinase domain (mutant) <BR />
+
**[[2x9f]], [[2vwy]] - hEPHR B4 kinase domain (mutant) <BR />
*''Ephrin B4 receptor binary complex''<br />
*''Ephrin B4 receptor binary complex''<br />
-
**[[2vwx]], [[2vwz]], [[2vx0]], [[2vx1]], [[2vwu]], [[2vwv]], [[2vww]], [[4aw5]] – hEPH B4 kinase domain + inhibitor <BR />
+
**[[2vwx]], [[2vwz]], [[2vx0]], [[2vx1]], [[2vwu]], [[2vwv]], [[2vww]], [[4aw5]] – hEPHR B4 kinase domain + inhibitor <BR />
-
**[[3zew]] - hEPH B4 + staurosporine<br />
+
**[[3zew]] - hEPHR B4 + staurosporine<br />
-
**[[2xvd]], [[2yn8]], [[4bb4]] - hEPH B4 kinase domain (mutant) + inhibitor<br />
+
**[[2xvd]], [[2yn8]], [[4bb4]] - hEPHR B4 kinase domain (mutant) + inhibitor<br />
-
**[[2hle]], [[2bba]] - hEPH B4 LBD + ephrin B2
+
**[[2hle]], [[2bba]] - hEPHR B4 LBD + ephrin B2
}}
}}

Revision as of 10:35, 30 March 2015

Image:3hei.png
Crystal Structure of ephrin A2 receptor complex with ephrin, 3hei

Template:STRUCTURE 3fxx

Ephrin receptors (EPHR) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPHR domains include an ectodomain (residues 23-435) containing the LBD (residues 23-326), a second fibronectin III domain (fn3) (residues 446-539), a transmembrane domain (residues 539-563), a kinase domain (residues 596-900) and a sterile-α-motif (SAM) domain (residues 908-972). For more details see Ephrin Type-A Receptor.








3D Structures of ephrin receptors

Updated on 30-March-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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