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Eukaryotic initiation factor

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'''Eukaryotic initiation factors''' (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG. For details on EIF4 see [[C-terminal portion of human eIF4GI]].
+
'''Eukaryotic initiation factors''' (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG. EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. For details on EIF4 see [[C-terminal portion of human eIF4GI]].
==3D structures of eukaryotic initiation factor==
==3D structures of eukaryotic initiation factor==
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**[[2if1]], [[1d7q]] – hEIF1 – human – NMR<BR />
**[[2if1]], [[1d7q]] – hEIF1 – human – NMR<BR />
**[[2ogh]] - yEIF1 – NMR<BR />
**[[2ogh]] - yEIF1 – NMR<BR />
 +
**[[3j80]], [[3j81]] – EIF1A in 40S ribosome – ''Kluyveromyces lactis'' – cryo EM<br />
 +
**[[4kzx]], [[4kzy]], [[4kzz]] – EIF1A in 40S ribosome – rabbit – cryo EM<br />
 +
**[[3zjy]] – hEIF1A + importin 13 + RanGTP<br />
*EIF2
*EIF2
-
**[[1kl9]] – hEIF2A<BR />
+
**[[1kl9]], [[1q8k]] – hEIF2A subunit 1<BR />
**[[1q8x ]]– hEIF2A - NMR<BR />
**[[1q8x ]]– hEIF2A - NMR<BR />
**[[1si2]], [[1si3]], [[4ei3]], [[4f3t]] – hEIF2C PAZ domain + DNA<BR />
**[[1si2]], [[1si3]], [[4ei3]], [[4f3t]] – hEIF2C PAZ domain + DNA<BR />
Line 24: Line 27:
**[[3lud]], [[3lug]], [[3luh]], [[3luj]], [[3qx8]], [[3qx9]] - hEIF2C MID domain + nucleotide<br />
**[[3lud]], [[3lug]], [[3luh]], [[3luj]], [[3qx8]], [[3qx9]] - hEIF2C MID domain + nucleotide<br />
**[[1q46]] – yEIF2A – yeast<BR />
**[[1q46]] – yEIF2A – yeast<BR />
 +
**[[3wj9]] - EIF2A – fission yeast<br />
**[[2a19]], [[2a1a]] – yEIF2A (mutant) + interferon-induced protein kinase<BR />
**[[2a19]], [[2a1a]] – yEIF2A (mutant) + interferon-induced protein kinase<BR />
**[[3ecs]] – hEIF2B
**[[3ecs]] – hEIF2B
Line 29: Line 33:
*EIF3
*EIF3
 +
**[[4k51]], [[4u1d]] - yEIF3A PCI domain<br />
**[[2nlw]] - hEIF3B RNA recognition domain – NMR<BR />
**[[2nlw]] - hEIF3B RNA recognition domain – NMR<BR />
**[[3ns5]], [[3ns6]] - yEIF3B RNA recognition domain<BR />
**[[3ns5]], [[3ns6]] - yEIF3B RNA recognition domain<BR />
 +
**[[4u1f]] - yEIF3B middle domain<br />
**[[2krb]] - hEIF3B RNA recognition domain + hEIF3J peptide<br />
**[[2krb]] - hEIF3B RNA recognition domain + hEIF3J peptide<br />
 +
**[[4nox]] – EIF3B – ''Chaetomium thermophilum''<br />
**[[2cq0]] – hEIF3G RNA recognition domain – NMR<BR />
**[[2cq0]] – hEIF3G RNA recognition domain – NMR<BR />
-
**[[3zwl]] - yEIF3I + EIF3B C terminal<BR />
+
**[[2mjc]] - hEIF3G residues 153-176 – NMR<br />
 +
**[[3zwl]] - yEIF3I + EIF3B CTD<BR />
 +
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
 +
**[[4u1e]] - yEIF3B CTD + yEIF3I + yEIF3G NTD<br />
**[[3bpj]] – hEIF3J<BR />
**[[3bpj]] – hEIF3J<BR />
-
**[[1rz4]] – hEIF3K
+
**[[1rz4]] – hEIF3K<br />
 +
**[[3j8b]], [[3j8c]] - hEIF3A + hEIF3C + hEIF3E + hEIF3F + hEIF3H + hEIF3K + hEIF3L + hEIF3M – cryo EM<br />
*EIF4
*EIF4
-
**[[1fuk]] – yEIF4A C terminal<BR />
+
**[[1fuk]] – yEIF4A CTD<BR />
**[[1fuu]] - yEIF4A mRNA helicase domain<BR />
**[[1fuu]] - yEIF4A mRNA helicase domain<BR />
**[[2g9n]], [[3bor]] – hEIF4A DEAD domain<BR />
**[[2g9n]], [[3bor]] – hEIF4A DEAD domain<BR />
-
**[[3ex7]], [[2xb2]] – hEIF4A + MAGO homolog + RNA-binding protein 8A + CASC3 + RNA<BR />
 
-
**[[2zu6]], [[3eiq]] – hEIF4A + programmed cell death protein<BR />
 
**[[1wi8]], [[2j76]] – hEIF4B RNA recognition domain - NMR<BR />
**[[1wi8]], [[2j76]] – hEIF4B RNA recognition domain - NMR<BR />
-
**[[1ejh]] – mEIF4E + EIF4G peptide + GDP – mouse<BR />
 
-
**[[1ej1]], [[1l8b]] - mEIF4E + nucleotide<br />
 
**[[2gpq]], [[3tf2]] – hEIF4E<BR />
**[[2gpq]], [[3tf2]] – hEIF4E<BR />
**[[2wmc]] - EIF4E - pea<BR />
**[[2wmc]] - EIF4E - pea<BR />
**[[2idr]] – wEIF4E – wheat<BR />
**[[2idr]] – wEIF4E – wheat<BR />
 +
**[[3l6a]] - hEIF4GII CTD<BR />
 +
**[[1ug3]] – hEIF4GI CTD (mutant)<br />
 +
**[[1hu3]], [[3d3m]], [[4iul]] – hEIF4GII middle domain<br />
 +
**[[2dng]] – hEIF4H RNA recognition domain – NMR<br />
 +
 +
*EIF4 complexes
 +
 +
**[[3ex7]], [[2xb2]] – hEIF4A + MAGO homolog + RNA-binding protein 8A + CASC3 + RNA<BR />
 +
**[[2zu6]], [[3eiq]] – hEIF4A + programmed cell death protein<BR />
 +
**[[4c9b]] - hEIF4A + CWC22<br />
 +
**[[2jgc]] - hEIF4E + 4E-BP1 peptide<br />
 +
**[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br />
 +
**[[4tpw]], [[4tqb]], [[4tqc]] - hEIF4E + nucleotide + inhibitor<br />
 +
**[[4bea]] - hEIF4E + stapled peptide<br />
 +
**[[1ejh]] – mEIF4E + EIF4G peptide + GDP – mouse<BR />
 +
**[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide<br />
**[[2idv]] - wEIF4E (mutant) + GDP<BR />
**[[2idv]] - wEIF4E (mutant) + GDP<BR />
**[[1ipb]], [[1ipc]] - hEIF4E + nucleotide<br />
**[[1ipb]], [[1ipc]] - hEIF4E + nucleotide<br />
**[[4dt6]], [[4dum]] – hEIF4E + inhibitor<BR />
**[[4dt6]], [[4dum]] – hEIF4E + inhibitor<BR />
-
**[[2w97]] – hEIF4E + hEIF4G peptide<br />
+
**[[2w97]], [[4aza]] – hEIF4E + hEIF4G peptide<br />
**[[1wkw]] - hEIF4E + EIF4E-binding protein peptide + GDP<BR />
**[[1wkw]] - hEIF4E + EIF4E-binding protein peptide + GDP<BR />
**[[2v8w]], [[2v8x]], [[2v8y]], [[3u7x]] - hEIF4E + EIF4E-binding protein peptide<br />
**[[2v8w]], [[2v8x]], [[2v8y]], [[3u7x]] - hEIF4E + EIF4E-binding protein peptide<br />
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**[[1rf8]] - yEIF4E + yEIF4GI peptide + GDP<BR />
**[[1rf8]] - yEIF4E + yEIF4GI peptide + GDP<BR />
**[[2vso]], [[2vsx]] - yEIF4E + yEIF4F<BR />
**[[2vso]], [[2vsx]] - yEIF4E + yEIF4F<BR />
-
**[[3l6a]] - hEIF4GII C terminal<BR />
+
**[[4axg]] - DmEIF4E + protein CUP – ''Drosophila melanogaster''<br />
-
**[[1ug3]] – hEIF4GI C terminal (mutant)<br />
+
**[[4ue8]], [[4uea]], [[4ueb]], [[4ued]] - DmEIF4E + 4E-binding protein <br />
-
**[[1hu3]], [[3d3m]] – hEIF4GII middle domain<br />
+
**[[4ue9]] - DmEIF4E + 4E transporter <br />
-
**[[2dng]] – hEIF4H RNA recognition domain – NMR<br />
+
**[[4uec]] - DmEIF4E + DmEIF4G <br />
*EIF5
*EIF5
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**[[3hks]] – EIF5A – ''Arabidopsis thaliana''<br />
**[[3hks]] – EIF5A – ''Arabidopsis thaliana''<br />
**[[3cpf]] - hEIF<br />
**[[3cpf]] - hEIF<br />
-
**[[2ful]] – yEIF5 C terminal<br />
+
**[[2ful]] – yEIF5 CTD<br />
-
**[[2iu1]] - hEIF5 C terminal<br />
+
**[[2iu1]] - hEIF5 CTD<br />
-
**[[2g2k]] – hEIF5 N terminal (mutant) – NMR<br />
+
**[[2g2k]] – hEIF5 NTD (mutant) – NMR<br />
**[[2e9h]] – hEIF5 – NMR<br />
**[[2e9h]] – hEIF5 – NMR<br />
**[[3cpf]] – hEIF5A<br />
**[[3cpf]] – hEIF5A<br />
**[[3er0]] - yEIF5A<br />
**[[3er0]] - yEIF5A<br />
 +
**[[3wbi]], [[3wbj]], [[4n3s]] – yEIF5B<br />
 +
**[[3wbk]] – yEIF5B + yEIF1A<br />
 +
**[[4ncf]] – yEIF5B + nucleotide<br />
*EIF6
*EIF6
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**[[1g62]] – yEIF6 <br />
**[[1g62]] – yEIF6 <br />
**[[2x7n]] – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24<br />
**[[2x7n]] – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24<br />
 +
**[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br />
}}
}}

Revision as of 07:02, 1 April 2015

Template:STRUCTURE 1ipb



Eukaryotic initiation factors (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG. EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. For details on EIF4 see C-terminal portion of human eIF4GI.

3D structures of eukaryotic initiation factor

Updated on 01-April-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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