2re9

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[[Image:2re9.jpg|left|200px]]<br /><applet load="2re9" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2re9.jpg|left|200px]]
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caption="2re9, resolution 2.100&Aring;" />
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'''Crystal structure of TL1A at 2.1 A'''<br />
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{{Structure
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|PDB= 2re9 |SIZE=350|CAPTION= <scene name='initialview01'>2re9</scene>, resolution 2.100&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY=
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|GENE= TNFSF15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal structure of TL1A at 2.1 A'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2RE9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RE9 OCA].
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2RE9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RE9 OCA].
==Reference==
==Reference==
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X-ray crystal structure of TNF ligand family member TL1A at 2.1A., Jin T, Guo F, Kim S, Howard A, Zhang YZ, Biochem Biophys Res Commun. 2007 Dec 7;364(1):1-6. Epub 2007 Oct 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17935696 17935696]
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X-ray crystal structure of TNF ligand family member TL1A at 2.1A., Jin T, Guo F, Kim S, Howard A, Zhang YZ, Biochem Biophys Res Commun. 2007 Dec 7;364(1):1-6. Epub 2007 Oct 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17935696 17935696]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: vegi]]
[[Category: vegi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:46:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:35:17 2008''

Revision as of 16:35, 20 March 2008

Image:2re9.jpg


PDB ID 2re9

Drag the structure with the mouse to rotate
, resolution 2.100Å
Ligands: and
Gene: TNFSF15 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of TL1A at 2.1 A


Overview

The TNF family has been one of the most intensively studied protein families in the past two decades and it has rapidly expanded through the era of genomics and bioinformatics. However, the structural basis of the functional and interactional similarities and differences of this family is poorly understood. TL1A is a recently identified TNF family member that has received increasing attention. Here, the crystal structure of human TL1A is reported. TL1A forms a homotrimer with each monomer assuming a jellyroll beta-sandwich fold. The CD loop in TL1A is the longest among the TNF ligand members with known structure and the AA' loop in TL1A is the second longest after that in TRAIL, where part of it is disordered. Both these loops are known to participate in receptor binding in TNFbeta/LTalpha. The AA' loop may be very different in other TL1A variants if the overall fold is to be preserved.

About this Structure

2RE9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of TNF ligand family member TL1A at 2.1A., Jin T, Guo F, Kim S, Howard A, Zhang YZ, Biochem Biophys Res Commun. 2007 Dec 7;364(1):1-6. Epub 2007 Oct 1. PMID:17935696

Page seeded by OCA on Thu Mar 20 18:35:17 2008

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