2rfn

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[[Image:2rfn.jpg|left|200px]]<br /><applet load="2rfn" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2rfn.jpg|left|200px]]
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caption="2rfn, resolution 2.50&Aring;" />
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'''x-ray structure of c-Met with inhibitor.'''<br />
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{{Structure
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|PDB= 2rfn |SIZE=350|CAPTION= <scene name='initialview01'>2rfn</scene>, resolution 2.50&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=AM7:2-benzyl-5-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-3-methylpyrimidin-4(3H)-one'>AM7</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1]
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|GENE= MET ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''x-ray structure of c-Met with inhibitor.'''
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==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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2RFN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=AM7:'>AM7</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFN OCA].
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2RFN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFN OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
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[[Category: tyrosine-protein kinase]]
[[Category: tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:46:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:35:45 2008''

Revision as of 16:35, 20 March 2008

Image:2rfn.jpg


PDB ID 2rfn

Drag the structure with the mouse to rotate
, resolution 2.50Å
Ligands:
Gene: MET (Homo sapiens)
Activity: Receptor protein-tyrosine kinase, with EC number 2.7.10.1
Coordinates: save as pdb, mmCIF, xml



x-ray structure of c-Met with inhibitor.


Disease

Known diseases associated with this structure: Autism, suseptibility to, 9 OMIM:[164860], Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860]

About this Structure

2RFN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Mar 20 18:35:45 2008

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