4py4
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of human poly(ADP-ribose) polymerase 14, catalytic domain in complex with an inhibitor XL2== | |
| - | + | <StructureSection load='4py4' size='340' side='right' caption='[[4py4]], [[Resolution|resolution]] 2.76Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4py4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PY4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XL2:2-({4-[(1R)-1-(DIMETHYLAMINO)ETHYL]PHENYL}AMINO)-6-FLUORO-1,3-BENZOTHIAZOLE-4-CARBOXAMIDE'>XL2</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4py4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4py4 RCSB], [http://www.ebi.ac.uk/pdbsum/4py4 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PAR14_HUMAN PAR14_HUMAN]] Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Li, J]] | [[Category: Li, J]] | ||
[[Category: Xu, Y]] | [[Category: Xu, Y]] | ||
| + | [[Category: Catalyze the post-translational modification of protein]] | ||
| + | [[Category: Rossmann fold]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
| + | [[Category: Using b-nad+]] | ||
Revision as of 13:19, 1 April 2015
Crystal structure of human poly(ADP-ribose) polymerase 14, catalytic domain in complex with an inhibitor XL2
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