4ufm
From Proteopedia
(Difference between revisions)
m (Protected "4ufm" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | ''' | + | ==Mouse Galactocerebrosidase complexed with 1-deoxy-galacto-nojirimycin DGJ== |
| - | + | <StructureSection load='4ufm' size='340' side='right' caption='[[4ufm]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ufm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UFM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DGJ:(2R,3S,4R,5S)-2-(HYDROXYMETHYL)PIPERIDINE-3,4,5-TRIOL'>DGJ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ufh|4ufh]], [[4ufi|4ufi]], [[4ufj|4ufj]], [[4ufk|4ufk]], [[4ufl|4ufl]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Galactosylceramidase Galactosylceramidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.46 3.2.1.46] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ufm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ufm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ufm RCSB], [http://www.ebi.ac.uk/pdbsum/4ufm PDBsum]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/GALC_MOUSE GALC_MOUSE]] Defects in Galc are the cause of the 'twitcher' phenotype; an autosomal recessive leukodystrophy similar to the human disease (Krabbe disease). This deficiency results in the insufficient catabolism of several galactolipids that are important in the production of normal myelin. |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GALC_MOUSE GALC_MOUSE]] Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.<ref>PMID:8769874</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Galactosylceramidase]] | ||
| + | [[Category: Christensen, S H]] | ||
| + | [[Category: Deane, J E]] | ||
| + | [[Category: Hill, C H]] | ||
| + | [[Category: Jensen, H H]] | ||
| + | [[Category: Moriarty, N W]] | ||
| + | [[Category: Read, R J]] | ||
[[Category: Salamone, S]] | [[Category: Salamone, S]] | ||
| - | [[Category: | + | [[Category: Spratley, S J]] |
| - | [[Category: | + | [[Category: Viuff, A H]] |
| - | [[Category: | + | [[Category: Complex]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | [[Category: | + | [[Category: Lysosome]] |
Revision as of 13:20, 1 April 2015
Mouse Galactocerebrosidase complexed with 1-deoxy-galacto-nojirimycin DGJ
| |||||||||||
