4uf7
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Ghanaian henipavirus (Gh-M74a) attachment glycoprotein in complex with human ephrinB2== |
| - | + | <StructureSection load='4uf7' size='340' side='right' caption='[[4uf7]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4uf7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UF7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uf7 RCSB], [http://www.ebi.ac.uk/pdbsum/4uf7 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | [[Category: Beaty, S | + | [[http://www.uniprot.org/uniprot/EFNB2_HUMAN EFNB2_HUMAN]] Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.<ref>PMID:12734395</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ahmed, A A]] | ||
| + | [[Category: Beaty, S M]] | ||
| + | [[Category: Bowden, T A]] | ||
| + | [[Category: Lee, B]] | ||
[[Category: Pernet, O]] | [[Category: Pernet, O]] | ||
[[Category: Zeltina, A]] | [[Category: Zeltina, A]] | ||
| - | [[Category: | + | [[Category: Gh-m74a]] |
| - | [[Category: | + | [[Category: Ghv-g]] |
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Hendra virus]] | ||
| + | [[Category: Hev-g]] | ||
| + | [[Category: Hnv]] | ||
| + | [[Category: Hnv-g]] | ||
| + | [[Category: Nipah virus]] | ||
| + | [[Category: Niv-g]] | ||
| + | [[Category: Paramyxovirus]] | ||
| + | [[Category: Viral attachment]] | ||
| + | [[Category: Viral protein-immune system complex]] | ||
Revision as of 13:20, 1 April 2015
Ghanaian henipavirus (Gh-M74a) attachment glycoprotein in complex with human ephrinB2
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Categories: Ahmed, A A | Beaty, S M | Bowden, T A | Lee, B | Pernet, O | Zeltina, A | Gh-m74a | Ghv-g | Glycoprotein | Hendra virus | Hev-g | Hnv | Hnv-g | Nipah virus | Niv-g | Paramyxovirus | Viral attachment | Viral protein-immune system complex
