4xnw
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==The human P2Y1 receptor in complex with MRS2500== |
| - | + | <StructureSection load='4xnw' size='340' side='right' caption='[[4xnw]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4xnw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XNW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2ID:[(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEX-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>2ID</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xnv|4xnv]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xnw RCSB], [http://www.ebi.ac.uk/pdbsum/4xnw PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/P2RY1_HUMAN P2RY1_HUMAN]] Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.<ref>PMID:9442040</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Gao, Z]] | [[Category: Gao, Z]] | ||
| - | [[Category: Han, G | + | [[Category: Han, G W]] |
| - | + | ||
[[Category: Jacobson, K]] | [[Category: Jacobson, K]] | ||
| + | [[Category: Stevens, R]] | ||
| + | [[Category: Wu, B]] | ||
| + | [[Category: Zhang, D]] | ||
[[Category: Zhao, Q]] | [[Category: Zhao, Q]] | ||
| + | [[Category: G protein coupled receptor]] | ||
| + | [[Category: Human p2y1 receptor]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Platelet activation]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 13:22, 1 April 2015
The human P2Y1 receptor in complex with MRS2500
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