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4yru
From Proteopedia
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| - | ''' | + | ==Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus== |
| - | + | <StructureSection load='4yru' size='340' side='right' caption='[[4yru]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yru]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YRU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yru RCSB], [http://www.ebi.ac.uk/pdbsum/4yru PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Derrick, J P]] | ||
[[Category: Karrupiah, V]] | [[Category: Karrupiah, V]] | ||
| - | + | [[Category: Lian, L Y]] | |
| - | [[Category: Lian, L | + | |
[[Category: Mayans, O]] | [[Category: Mayans, O]] | ||
| - | [[Category: | + | [[Category: Pandalaneni, S]] |
| + | [[Category: C-terminal truncation]] | ||
| + | [[Category: Calcium sensor]] | ||
| + | [[Category: Ef-hand]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 13:23, 1 April 2015
Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus
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