5air
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Structural analysis of mouse GSK3beta fused with LRP6 peptide.== |
| - | + | <StructureSection load='5air' size='340' side='right' caption='[[5air]], [[Resolution|resolution]] 2.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5air]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AIR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5air FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5air OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5air RCSB], [http://www.ebi.ac.uk/pdbsum/5air PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Coronary artery disease - hyperlipidemia - hypertension - diabetes - osteoporosis. The disease is caused by mutations affecting the gene represented in this entry. |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).<ref>PMID:11448771</ref> <ref>PMID:11357136</ref> <ref>PMID:15778503</ref> <ref>PMID:16341017</ref> <ref>PMID:16513652</ref> <ref>PMID:17400545</ref> <ref>PMID:17326769</ref> <ref>PMID:19107203</ref> <ref>PMID:19801552</ref> <ref>PMID:19293931</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kim, K L]] | ||
| + | [[Category: Gsk3 beta]] | ||
| + | [[Category: Lrp6]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 13:24, 1 April 2015
Structural analysis of mouse GSK3beta fused with LRP6 peptide.
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Categories: Kim, K L | Gsk3 beta | Lrp6 | Transferase
