2rmc
From Proteopedia
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| - | [[Image:2rmc.gif|left|200px]] | + | [[Image:2rmc.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF MURINE CYCLOPHILIN C COMPLEXED WITH IMMUNOSUPPRESSIVE DRUG CYCLOSPORIN A''' | + | {{Structure |
| + | |PDB= 2rmc |SIZE=350|CAPTION= <scene name='initialview01'>2rmc</scene>, resolution 1.64Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF MURINE CYCLOPHILIN C COMPLEXED WITH IMMUNOSUPPRESSIVE DRUG CYCLOSPORIN A''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2RMC is a [ | + | 2RMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMC OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A., Ke H, Zhao Y, Luo F, Weissman I, Friedman J, Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11850-4. PMID:[http:// | + | Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A., Ke H, Zhao Y, Luo F, Weissman I, Friedman J, Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11850-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8265636 8265636] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: complex (isomerase/immunosuppressant)]] | [[Category: complex (isomerase/immunosuppressant)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:37:28 2008'' |
Revision as of 16:37, 20 March 2008
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| , resolution 1.64Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | CYCLOPHILIN (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF MURINE CYCLOPHILIN C COMPLEXED WITH IMMUNOSUPPRESSIVE DRUG CYCLOSPORIN A
Overview
Cyclophilin is a cellular receptor for the immunosuppressive drug cyclosporin A (CsA). Cyclophilin C (CyPC) is highly expressed in murine kidney, making it a potential mediator of the nephrotoxic effects of CsA. The structure of murine CyPC complexed with CsA has been solved and refined to an R factor of 0.197 at a 1.64-A resolution. Superposition of the CyPC-CsA structure with the unligated cyclophilin A (CyPA) revealed significant migration of three loops: Gln-179 to Thr-189, Asp-47 to Lys-49, and Met-170 to Ile-176. The proximity of the loop Gln-179 to Thr-189 to the CsA binding site may account for the unique binding of a 77-kDa glycoprotein, CyPC binding protein (CyCAP), to CyPC. The binding of CsA to CyPC is similar to that of CsA to human T-cell cyclophilin A (CyPA). However, the conformation of CsA when bound to CyPC is significantly different from that when bound to CyPA. These differences may reflect conformational variation of CsA when bound to different proteins. Alternatively, the previous CyPA-CsA structure at low resolution may not provide sufficient details for a comparison with the CyPC-CsA structure.
About this Structure
2RMC is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A., Ke H, Zhao Y, Luo F, Weissman I, Friedman J, Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11850-4. PMID:8265636
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