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Overview

Mycobacterium tuberculosis NrdH is a small glutaredoxin-like protein involved in the electron transport chain that eventually leads to ribonucleotide reduction.

Background

Mycobacterium tuberculosis resides in the lungs of a host and upon becoming active, results in symptoms such as chest pains, weakness, and intense coughing. Left untreated and unmanaged, TB can lead to death (1.5 million in 2013). The disease has a high co-morbidity with HIV/AIDS due to its immunocompromising tendencies. Tuberculosis is one of the most heavily studied diseases today. With over 9 million infections worldwide per year, the necessity for antimicrobial agents to combat emerging multi-drug resistant strands is imperative.

Structure

The structure of M. tuberculosis as determined by x-ray crystallography has 79 residues in a single polypeptide chain. . The active site is dominated by a disulphide bond between Cys-11 and Cys-14, which serves as the site of reduction by Theirodoxin reductase.

Function

Disease

Relevance

Structural highlights

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