Galectin

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Line 7: Line 7:
* GAL-4 has 2 CRDs.<br />
* GAL-4 has 2 CRDs.<br />
* GAL-7 is associated with epithelial cells.<br />
* GAL-7 is associated with epithelial cells.<br />
-
* GAL-8 has a role in cellular defence against bacterial infection and vacuolar damage.<br />
+
* GAL-8 has a role in cellular defense against bacterial infection and vacuolar damage.<br />
* GAL-9 affects eosinophil survival. <br />
* GAL-9 affects eosinophil survival. <br />
* GAL-10 or Charcot-Leyden crystal protein acts on biological membranes to regulate the multifunctional lysophospholipids.
* GAL-10 or Charcot-Leyden crystal protein acts on biological membranes to regulate the multifunctional lysophospholipids.
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**[[1gan]] – tGAL-1 + BGAL – toad<br />
**[[1gan]] – tGAL-1 + BGAL – toad<br />
**[[1a78]] – tGAL-1 + thio-digalactose<br />
**[[1a78]] – tGAL-1 + thio-digalactose<br />
-
**[[3m2m]], [[4ga9]] - GAL-1 + lactose – rat
+
**[[3m2m]], [[4ga9]] - rGAL-1 + lactose – rat<br />
 +
**[[4no4]] - rGAL-1 (mutant) + lactose<br />
 +
**[[4lbq]] – mGAL-1 – mouse<br />
*Galectin-2
*Galectin-2
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**[[1a3k]], [[1kjl]], [[2nmn]] – hGAL-3 CRD + BGAL<br />
**[[1a3k]], [[1kjl]], [[2nmn]] – hGAL-3 CRD + BGAL<br />
**[[2nmo]] - hGAL-3 CRD + glucose + BGAL<br />
**[[2nmo]] - hGAL-3 CRD + glucose + BGAL<br />
-
**[[2nn8]], [[3aye]], [[3zsj]] - hGAL-3 CRD + lactose<br />
+
**[[2nn8]], [[3aye]], [[3zsj]], [[4r9a]], [[4r9b]], [[4r9c]], [[4r9d]], [[4rl7]] - hGAL-3 CRD + lactose<br />
**[[1kjr ]]– hGAL-3 CRD + acetyllactosamine<br />
**[[1kjr ]]– hGAL-3 CRD + acetyllactosamine<br />
**[[2xg3]], [[3t1l]], [[3t1m]] - hGAL-3 CRD + inhibitor<br />
**[[2xg3]], [[3t1l]], [[3t1m]] - hGAL-3 CRD + inhibitor<br />
**[[3aya]] - hGAL-3 CRD + antigen<br />
**[[3aya]] - hGAL-3 CRD + antigen<br />
**[[3ayc]], [[3ayd]], [[4jc1]], [[4jck]] - hGAL-3 CRD + polysaccharide<br />
**[[3ayc]], [[3ayd]], [[4jc1]], [[4jck]] - hGAL-3 CRD + polysaccharide<br />
-
**[[4lbj]], [[4lbk]], [[4lbl]], [[4lbm]], [[4lbn]], [[4lbo]] - hGAL-8 CRD (mutant) + glycosphingolipid<br />
+
**[[4lbj]], [[4lbk]], [[4lbl]], [[4lbm]], [[4lbn]], [[4lbo]] - hGAL-3 CRD (mutant) + glycosphingolipid<br />
 +
**[[4bli]], [[4blj]], [[4bm8]] - hGAL-3 CRD + thiogalactoside derivative<br />
*Galectin-4
*Galectin-4
**[[1x50]] – hGAL-4 CRD – NMR<BR />
**[[1x50]] – hGAL-4 CRD – NMR<BR />
-
**[[2dyc]] – mGAL-4 CRD – mouse<br />
+
**[[2dyc]] – mGAL-4 CRD <br />
**[[3i8t]] – mGAL-4 + lactose<br />
**[[3i8t]] – mGAL-4 + lactose<br />
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**[[5gal]] – hGAL-7 + acetyllactosamine<br />
**[[5gal]] – hGAL-7 + acetyllactosamine<br />
**[[3zxe]] - hGAL-7 + inhibitor<br />
**[[3zxe]] - hGAL-7 + inhibitor<br />
 +
**[[4uw3]], [[4uw4]], [[4uw5]], [[4uw6]] – hGAL-7 + galactose-based dendron<br />
*Galectin-8
*Galectin-8
Line 82: Line 86:
**[[2yv8]] – hGAL-8 N terminal<br />
**[[2yv8]] – hGAL-8 N terminal<br />
**[[3ojb]] - hGAL-8 C terminal<br />
**[[3ojb]] - hGAL-8 C terminal<br />
-
**[[2yxs]] – hGAL-8 N terminal + lactose<br />
+
**[[2yxs]], [[4bmb]] – hGAL-8 N terminal + lactose<br />
 +
**[[4bme]] – hGAL-8 N terminal (mutant) + lactose<br />
**[[2yy1]] – hGAL-8 N terminal + acetyllactosamine<br />
**[[2yy1]] – hGAL-8 N terminal + acetyllactosamine<br />
Line 94: Line 99:
**[[3nv1]] – hGAL-9 CRD<br />
**[[3nv1]] – hGAL-9 CRD<br />
**[[3lse]] – hGAL-9 N terminal + lactose<br />
**[[3lse]] – hGAL-9 N terminal + lactose<br />
-
**[[2eak]] - hGAL-9 CRD + lactose<br />
+
**[[2eak]], [[3wlu]] - hGAL-9 CRD + lactose<br />
**[[3nv4]] - hGAL-9 CRD + sialyllactose<br />
**[[3nv4]] - hGAL-9 CRD + sialyllactose<br />
**[[2zhk]], [[2zhl]], [[2zhm]], [[2zhn]], [[3nv2]] - hGAL-9 CRD + acetyllactosamine<br />
**[[2zhk]], [[2zhl]], [[2zhm]], [[2zhn]], [[3nv2]] - hGAL-9 CRD + acetyllactosamine<br />

Revision as of 08:41, 6 April 2015

Structure of human galectin-1 complex with lactose (PDB entry 1hlc)

Drag the structure with the mouse to rotate

3D structures of galectin

Updated on 06-April-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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