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2seb
From Proteopedia
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| - | [[Image:2seb.jpg|left|200px]] | + | [[Image:2seb.jpg|left|200px]] |
| - | + | ||
| - | '''X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II''' | + | {{Structure |
| + | |PDB= 2seb |SIZE=350|CAPTION= <scene name='initialview01'>2seb</scene>, resolution 2.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==Disease== | ==Disease== | ||
| - | Known diseases associated with this structure: Achondrogenesis-hypochondrogenesis, type II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], Epiphyseal dysplasia, multiple, with myopia and deafness OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], Kniest dysplasia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], Osteoarthrosis | + | Known diseases associated with this structure: Achondrogenesis-hypochondrogenesis, type II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], Epiphyseal dysplasia, multiple, with myopia and deafness OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], Kniest dysplasia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], Osteoarthrosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], SED congenita OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], SED, Namaqualand type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], SMED Strudwick type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], Spondyloperipheral dysplasia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], Stickler syndrome, type I OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]], Vitreoretinopathy with phalangeal epiphyseal dysplasia ( OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120140 120140]] |
==About this Structure== | ==About this Structure== | ||
| - | 2SEB is a [ | + | 2SEB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SEB OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II., Dessen A, Lawrence CM, Cupo S, Zaller DM, Wiley DC, Immunity. 1997 Oct;7(4):473-81. PMID:[http:// | + | X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II., Dessen A, Lawrence CM, Cupo S, Zaller DM, Wiley DC, Immunity. 1997 Oct;7(4):473-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9354468 9354468] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: complex (mhc class ii/superantigen)]] | [[Category: complex (mhc class ii/superantigen)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:38:15 2008'' |
Revision as of 16:38, 20 March 2008
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| , resolution 2.5Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II
Contents |
Overview
Genetic predisposition to rheumatoid arthritis (RA) is linked to the MHC class II allele HLA-DR4. The charge of the amino acid at DRbeta71 in the peptide-binding site appears to be critical in discriminating DR molecules linked to increased disease susceptibility. We have determined the 2.5 A x-ray structure of the DR4 molecule with the strongest linkage to RA (DRB1*0401) complexed with a human collagen II peptide. Details of a predicted salt bridge between lysine DRbeta71 and aspartic acid at the P4 peptide position suggest how it may participate in both antigen binding and TCR activation. A model is proposed for the DR4 recognition of collagen II (261-273), an antigen immunodominant in human-transgenic mouse models of RA.
Disease
Known diseases associated with this structure: Achondrogenesis-hypochondrogenesis, type II OMIM:[120140], Epiphyseal dysplasia, multiple, with myopia and deafness OMIM:[120140], Kniest dysplasia OMIM:[120140], Osteoarthrosis OMIM:[120140], SED congenita OMIM:[120140], SED, Namaqualand type OMIM:[120140], SMED Strudwick type OMIM:[120140], Spondyloperipheral dysplasia OMIM:[120140], Stickler syndrome, type I OMIM:[120140], Vitreoretinopathy with phalangeal epiphyseal dysplasia ( OMIM:[120140]
About this Structure
2SEB is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II., Dessen A, Lawrence CM, Cupo S, Zaller DM, Wiley DC, Immunity. 1997 Oct;7(4):473-81. PMID:9354468
Page seeded by OCA on Thu Mar 20 18:38:15 2008
