User:Braden Sciarra/Sandbox 1
From Proteopedia
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<StructureSection load='1F8I' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1F8I' size='340' side='right' caption='Caption for this structure' scene=''> | ||
- | [http://en.wikipedia.org/wiki/Isocitrate_lyase Isocitrate Lyase] | + | [http://en.wikipedia.org/wiki/Isocitrate_lyase Isocitrate Lyase] (ICL) is a metabolic enzyme that converts the metabolite isocitrate into glyoxylate and succinate. ICL is a homotetramer with each monomer being composed of 14 alpha helices, 14 beta sheets, and a magnesium ion cofactor. ICL has shown clinical relevance in the disease state [http://en.wikipedia.org/wiki/Tuberculosis Tuberculosis] where it is responsible for the persistence of Mycobacterium tuberculosis during the chronic stage of infection. This survival strategy mediated by ICL is characterized by a metabolic shortcut within the [http://en.wikipedia.org/wiki/Citric_acid_cycle Citric Acid Cycle]. ICL creates this shunt pathway by converting isocitrate to succinate and glyoxylate, diverting acetyl-CoA from the beta-oxidation of fatty acids. |
[http://en.wikipedia.org/wiki/Tuberculosis Tuberculosis] | [http://en.wikipedia.org/wiki/Tuberculosis Tuberculosis] |
Revision as of 22:27, 7 April 2015
Isocitrate Lyase from Mycobacterium Tuberculosis
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