2tgi

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[[Image:2tgi.gif|left|200px]]<br /><applet load="2tgi" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2tgi.gif|left|200px]]
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caption="2tgi, resolution 1.8&Aring;" />
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'''CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA2: AN UNUSUAL FOLD FOR THE SUPERFAMILY'''<br />
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{{Structure
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|PDB= 2tgi |SIZE=350|CAPTION= <scene name='initialview01'>2tgi</scene>, resolution 1.8&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA2: AN UNUSUAL FOLD FOR THE SUPERFAMILY'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2TGI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TGI OCA].
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2TGI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TGI OCA].
==Reference==
==Reference==
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Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily., Daopin S, Piez KA, Ogawa Y, Davies DR, Science. 1992 Jul 17;257(5068):369-73. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1631557 1631557]
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Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily., Daopin S, Piez KA, Ogawa Y, Davies DR, Science. 1992 Jul 17;257(5068):369-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1631557 1631557]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: growth factor]]
[[Category: growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:49:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:39:01 2008''

Revision as of 16:39, 20 March 2008

Image:2tgi.gif


PDB ID 2tgi

Drag the structure with the mouse to rotate
, resolution 1.8Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA2: AN UNUSUAL FOLD FOR THE SUPERFAMILY


Overview

The transforming growth factors-beta (TGF-beta 1 through -beta 5) are a family of homodimeric cytokines that regulate proliferation and function in many cell types. Family members have 66 to 80% sequence identity and nine strictly conserved cysteines. A crystal structure of a member of this family, TGF-beta 2, has been determined at 2.1 angstrom (A) resolution and refined to an R factor of 0.172. The monomer lacks a well-defined hydrophobic core and displays an unusual elongated nonglobular fold with dimensions of approximately 60 A by 20 A by 15 A. Eight cysteines form four intrachain disulfide bonds, which are clustered in a core region forming a network complementary to the network of hydrogen bonds. The dimer is stabilized by the ninth cysteine, which forms an interchain disulfide bond, and by two identical hydrophobic interfaces. Sequence profile analysis of other members of the TGF-beta superfamily, including the activins, inhibins, and several developmental factors, imply that they also adopt the TGF-beta fold.

About this Structure

2TGI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily., Daopin S, Piez KA, Ogawa Y, Davies DR, Science. 1992 Jul 17;257(5068):369-73. PMID:1631557

Page seeded by OCA on Thu Mar 20 18:39:01 2008

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