4run
From Proteopedia
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| - | ''' | + | ==Crystal structure of human odorant binding protein OBPIIa== |
| + | <StructureSection load='4run' size='340' side='right' caption='[[4run]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4run]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RUN FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4run FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4run OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4run RCSB], [http://www.ebi.ac.uk/pdbsum/4run PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/OBP2A_HUMAN OBP2A_HUMAN]] Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids.<ref>PMID:12044155</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Human odorant-binding protein, OBPIIa , is expressed by nasal epithelia to facilitate transport of hydrophobic odorant molecules across the aqueous mucus. Here, we report its crystallographic analysis at 2.6 A resolution. OBPIIa is a monomeric protein that exhibits the classical lipocalin fold with a conserved eight-stranded beta-barrel harboring a remarkably large hydrophobic pocket. Basic residues within the four loops that shape the entrance to this ligand-binding site evoke a positive electrostatic potential. Human OBPIIa shows distinct features compared with other mammalian OBPs, including a potentially reactive Cys side chain within its pocket similar to human tear lipocalin. Proteins 2015. (c) 2015 Wiley Periodicals, Inc. | ||
| - | + | Crystal structure of the human odorant binding protein, OBP.,Schiefner A, Freier R, Eichinger A, Skerra A Proteins. 2015 Mar 21. doi: 10.1002/prot.24797. PMID:25810031<ref>PMID:25810031</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Schiefner, A]] | ||
[[Category: Skerra, A]] | [[Category: Skerra, A]] | ||
| - | [[Category: | + | [[Category: Aliphatic aldehyde]] |
| + | [[Category: Fatty acid]] | ||
| + | [[Category: Human lipocalin]] | ||
| + | [[Category: Lilial]] | ||
| + | [[Category: Lipid binding protein]] | ||
| + | [[Category: Nasal mucus]] | ||
| + | [[Category: Odorant-binding protein]] | ||
| + | [[Category: Transport protein]] | ||
| + | [[Category: Vanillin]] | ||
Revision as of 11:02, 8 April 2015
Crystal structure of human odorant binding protein OBPIIa
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