4v39
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Apo-structure of alpha2,3-sialyltransferase variant 2 from Pasteurella dagmatis== |
| + | <StructureSection load='4v39' size='340' side='right' caption='[[4v39]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4v39]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V39 FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4v2u|4v2u]], [[4v38|4v38]], [[4v3b|4v3b]], [[4v3c|4v3c]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v39 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v39 RCSB], [http://www.ebi.ac.uk/pdbsum/4v39 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Structure-guided active-site redesign of a family GT-80 beta-D-galactoside sialyltransferase (from Pasteurella dagmatis) to change enzyme regioselectivity from alpha-2,3 in the wild type to alpha-2,6 in a P7H-M117A double mutant is reported. Biochemical data for sialylation of lactose together with protein crystal structures demonstrate highly precise enzyme engineering. | ||
| - | + | Complete switch from alpha-2,3- to alpha-2,6-regioselectivity in Pasteurella dagmatis beta-D-galactoside sialyltransferase by active-site redesign.,Schmolzer K, Czabany T, Luley-Goedl C, Pavkov-Keller T, Ribitsch D, Schwab H, Gruber K, Weber H, Nidetzky B Chem Commun (Camb). 2015 Feb 21;51(15):3083-6. doi: 10.1039/c4cc09772f. PMID:25619424<ref>PMID:25619424</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Czabany, T]] | ||
| + | [[Category: Gruber, K]] | ||
[[Category: Luley-Goedl, C]] | [[Category: Luley-Goedl, C]] | ||
[[Category: Nidetzky, B]] | [[Category: Nidetzky, B]] | ||
| - | [[Category: Czabany, T]] | ||
[[Category: Pavkov-Keller, T]] | [[Category: Pavkov-Keller, T]] | ||
| + | [[Category: Ribitsch, D]] | ||
[[Category: Schmoelzer, K]] | [[Category: Schmoelzer, K]] | ||
| - | [[Category: Gruber, K]] | ||
[[Category: Schwab, H]] | [[Category: Schwab, H]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 11:04, 8 April 2015
Apo-structure of alpha2,3-sialyltransferase variant 2 from Pasteurella dagmatis
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