4cva
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==MPS1 kinase with 3-aminopyridin-2-one inhibitors== |
| - | + | <StructureSection load='4cva' size='340' side='right' caption='[[4cva]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4cva]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CVA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WBI:N-(6-OXO-1,6-DIHYDRO-3,4-BIPYRIDIN-5-YL)-4-(PIPERIDIN-1-YL)BENZAMIDE'>WBI</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cv8|4cv8]], [[4cv9|4cv9]]</td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cva RCSB], [http://www.ebi.ac.uk/pdbsum/4cva PDBsum]</span></td></tr> |
| - | [ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dual-specificity kinase]] | ||
[[Category: Bavetsias, V]] | [[Category: Bavetsias, V]] | ||
[[Category: Bayliss, R]] | [[Category: Bayliss, R]] | ||
| + | [[Category: Fearon, D]] | ||
| + | [[Category: Jones, K]] | ||
| + | [[Category: Schmitt, J]] | ||
| + | [[Category: Westwood, I M]] | ||
| + | [[Category: VanMontfort, R L.M]] | ||
| + | [[Category: Fragment]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 11:11, 8 April 2015
MPS1 kinase with 3-aminopyridin-2-one inhibitors
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