4y2b
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A== |
| - | + | <StructureSection load='4y2b' size='340' side='right' caption='[[4y2b]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4y2b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y2B FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPK:3-ETHYL-2-(PROPAN-2-YLAMINO)-7-(PYRIDIN-3-YL)THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE'>EPK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y2b RCSB], [http://www.ebi.ac.uk/pdbsum/4y2b PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [ | + | == Function == |
| - | [ | + | [[http://www.uniprot.org/uniprot/PDE7A_HUMAN PDE7A_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.<ref>PMID:19350606</ref> |
| - | [[ | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: 3',5'-cyclic-AMP phosphodiesterase]] | ||
[[Category: Amano, S]] | [[Category: Amano, S]] | ||
| - | [[Category: Onodera, Y]] | ||
| - | [[Category: Irie, T]] | ||
| - | [[Category: Takahashi, N]] | ||
| - | [[Category: Asanuma, Y]] | ||
[[Category: Asano, T]] | [[Category: Asano, T]] | ||
| + | [[Category: Asanuma, Y]] | ||
[[Category: Endo, Y]] | [[Category: Endo, Y]] | ||
| + | [[Category: Irie, T]] | ||
| + | [[Category: Kamei, N]] | ||
| + | [[Category: Kawai, K]] | ||
| + | [[Category: Onodera, Y]] | ||
[[Category: Sawada, K]] | [[Category: Sawada, K]] | ||
| + | [[Category: Sonoda, Y]] | ||
| + | [[Category: Takahashi, N]] | ||
| + | [[Category: Ueo, N]] | ||
| + | [[Category: Camp]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Pde7a]] | ||
| + | [[Category: Phosphodiesterase]] | ||
Revision as of 11:19, 8 April 2015
Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A
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