4ymd

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m (Protected "4ymd" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==CL-K1 trimer bound to man(alpha1-2)man==
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<StructureSection load='4ymd' size='340' side='right' caption='[[4ymd]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
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The entry 4ymd is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ymd]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YMD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YMD FirstGlance]. <br>
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Authors: Wallis, R., Venkatraman Girija, U., Gingras, A.R., Moody, P.C.E., Marshall, J.E.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ymd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ymd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ymd RCSB], [http://www.ebi.ac.uk/pdbsum/4ymd PDBsum]</span></td></tr>
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Description: CL-K1 trimer bound to man(alpha1-2)man
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</table>
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[[Category: Unreleased Structures]]
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== Disease ==
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[[Category: Venkatraman Girija, U]]
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[[http://www.uniprot.org/uniprot/COL11_HUMAN COL11_HUMAN]] Craniofacial-ulnar-renal syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Marshall, J.E]]
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== Function ==
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[[Category: Gingras, A.R]]
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[[http://www.uniprot.org/uniprot/COL11_HUMAN COL11_HUMAN]] Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity).
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[[Category: Moody, P.C.E]]
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__TOC__
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</StructureSection>
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[[Category: Gingras, A R]]
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[[Category: Girija, U Venkatraman]]
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[[Category: Marshall, J E]]
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[[Category: Moody, P C.E]]
[[Category: Wallis, R]]
[[Category: Wallis, R]]
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[[Category: C-type carbohydrate-recognition domain]]
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[[Category: C-type lectin]]
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[[Category: Collectin]]
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[[Category: Sugar binding protein]]

Revision as of 11:19, 8 April 2015

CL-K1 trimer bound to man(alpha1-2)man

4ymd, resolution 2.87Å

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