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Sandbox Reserved 1073

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=== FAS-II System ===
=== FAS-II System ===
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[http://en.wikipedia.org/wiki/Mycolic_acid Mycolic acids] are very long-chain fatty acids (C<sub>60< that are essential components of the mycobacterial cell wall. Mycolic acids are synthesized by at least two known elongation systems, type I and type II [http://en.wikipedia.org/wiki/Fatty_acid_synthase fatty acid synthases] (FAS-I and FAS-II). The FAS-II system prefers C16 as a starting substrate and can extend up to C56. The FAS-II system utilizes the products from the FAS-I system as primers to extend the chain lengths further. The products of the FAS-II system are the precursors of mycolic acids. Elongation by the FAS-II system occurs by a [http://en.wikipedia.org/wiki/Condensation_reaction condensation reaction], which is achieved in three steps. Step 1 involves transfer of the acyl primer, step 2 involves [http://en.wikipedia.org/wiki/Decarboxylation decarboxylation] of the substrate to yield a [http://en.wikipedia.org/wiki/Carbanion carbanion], and step 3 involves nucleophilic attack of the carbanion to yield the elongated product.
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[http://en.wikipedia.org/wiki/Mycolic_acid Mycolic acids] are very long-chain fatty acids (C<sub>60</sub> -C<sub>90</sub>) that are essential components of the mycobacterial cell wall. Mycolic acids are synthesized by at least two known elongation systems, type I and type II [http://en.wikipedia.org/wiki/Fatty_acid_synthase fatty acid synthases] (FAS-I and FAS-II). The FAS-II system prefers C16 as a starting substrate and can extend up to C56. The FAS-II system utilizes the products from the FAS-I system as primers to extend the chain lengths further. The products of the FAS-II system are the precursors of mycolic acids. Elongation by the FAS-II system occurs by a [http://en.wikipedia.org/wiki/Condensation_reaction condensation reaction], which is achieved in three steps. Step 1 involves transfer of the acyl primer, step 2 involves [http://en.wikipedia.org/wiki/Decarboxylation decarboxylation] of the substrate to yield a [http://en.wikipedia.org/wiki/Carbanion carbanion], and step 3 involves nucleophilic attack of the carbanion to yield the elongated product.
=== Mechanism of Action ===
=== Mechanism of Action ===

Revision as of 20:10, 8 April 2015

This Sandbox is Reserved from 02/09/2015, through 05/31/2016 for use in the course "CH462: Biochemistry 2" taught by Geoffrey C. Hoops at the Butler University. This reservation includes Sandbox Reserved 1051 through Sandbox Reserved 1080.
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Enoyl-ACP Reductase InhA

Enoyl-ACP Reductase InhA Homotetramer

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