Sandbox Reserved 1071
From Proteopedia
(Difference between revisions)
| Line 21: | Line 21: | ||
<scene name='69/694238/N_terminus/2'>hook</scene> | <scene name='69/694238/N_terminus/2'>hook</scene> | ||
| - | |||
| - | There are 6 conserved key active site residues that suround the <scene name='69/694238/Heme/2'>heme</scene>. These <scene name='69/694238/Active_site/2'>active site</scene> residues are Arg 104, Trp 107, His 108, His 270, Asp 381. | ||
[[Image:INH.png|300 px|left|thumb|Figure Legend]] | [[Image:INH.png|300 px|left|thumb|Figure Legend]] | ||
| + | |||
| + | There are 6 conserved key active site residues that suround the <scene name='69/694238/Heme/2'>heme</scene>. These <scene name='69/694238/Active_site/2'>active site</scene> residues are Arg 104, Trp 107, His 108, His 270, Asp 381. | ||
| + | |||
| + | The location of the binding site for isoniazid (INH) is located near the ''delta meso'' heme edge, about 3.8 A away from the heme iron. This binding site is found within what is considered to be the usual substrate access channel of peroxidases. The reaction between INH and the enzyme must occur from interaction in a binding site intended for the natural substrate. Asp 137 plays a key role in the activation and binding of INH. Asp 137 creates energetically favorable interactions due to its ability to make hydrogen-bond interactions between its carboxylic acid side chain and the pyridinyl N1 of INH. | ||
| + | |||
| + | |||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 00:16, 9 April 2015
| This Sandbox is Reserved from 02/09/2015, through 05/31/2016 for use in the course "CH462: Biochemistry 2" taught by Geoffrey C. Hoops at the Butler University. This reservation includes Sandbox Reserved 1051 through Sandbox Reserved 1080. |
To get started:
More help: Help:Editing |
Mycobacterium tuberculosis Catalase-Peroxidase
| |||||||||||
