Sandbox PgpWWC
From Proteopedia
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'''P-glycoprotein (P-gp, ABCB1)''' is an ATP casette transporter that hydrolyses ATP for conformational changes after a variety of substrates are transported. It is one of the membrane proteins responsible for the multi drug resistance (MDR) in cancer treatment, as well as various other drug therapies (Aller et. al 2009; He and Liu 2002). P-gp can be found in tumor cells, as well as in the liver, kidney, adrenal gland, intestine, blood-brain barrier (BBB), placenta, blood-testis barrier, and blood-ovarian barriers. An effective MDR transport protein, the high amount of active Pgp substrates stems from the polyspecificity for hydrophobic and aromatic compounds (Marchetti, Mazzanti, Beijnen, & Schellens 2007). | '''P-glycoprotein (P-gp, ABCB1)''' is an ATP casette transporter that hydrolyses ATP for conformational changes after a variety of substrates are transported. It is one of the membrane proteins responsible for the multi drug resistance (MDR) in cancer treatment, as well as various other drug therapies (Aller et. al 2009; He and Liu 2002). P-gp can be found in tumor cells, as well as in the liver, kidney, adrenal gland, intestine, blood-brain barrier (BBB), placenta, blood-testis barrier, and blood-ovarian barriers. An effective MDR transport protein, the high amount of active Pgp substrates stems from the polyspecificity for hydrophobic and aromatic compounds (Marchetti, Mazzanti, Beijnen, & Schellens 2007). | ||
{{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}} | {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}} | ||
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== Function == | == Function == | ||
Revision as of 15:43, 9 April 2015
P-glycoprotein
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