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2uwo

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[[Image:2uwo.jpg|left|200px]]<br /><applet load="2uwo" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2uwo.jpg|left|200px]]
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caption="2uwo, resolution 1.75&Aring;" />
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'''SELECTIVE AND DUAL ACTION ORALLY ACTIVE INHIBITORS OF THROMBIN AND FACTOR XA'''<br />
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{{Structure
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|PDB= 2uwo |SIZE=350|CAPTION= <scene name='initialview01'>2uwo</scene>, resolution 1.75&Aring;
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|SITE= <scene name='pdbsite=AC1:701+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=701:(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE'>701</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6]
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|GENE=
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}}
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'''SELECTIVE AND DUAL ACTION ORALLY ACTIVE INHIBITORS OF THROMBIN AND FACTOR XA'''
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==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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2UWO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=701:'>701</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Known structural/functional Site: <scene name='pdbsite=AC1:701+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWO OCA].
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2UWO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWO OCA].
[[Category: Coagulation factor Xa]]
[[Category: Coagulation factor Xa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: blood coagulation]]
[[Category: blood coagulation]]
[[Category: calcium]]
[[Category: calcium]]
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[[Category: cleavage on pair of basic residues]]
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[[Category: cleavage on pair of basic residue]]
[[Category: complex]]
[[Category: complex]]
[[Category: egf-like domain]]
[[Category: egf-like domain]]
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[[Category: zymogen]]
[[Category: zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:51:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:40:45 2008''

Revision as of 16:40, 20 March 2008

Image:2uwo.jpg


PDB ID 2uwo

Drag the structure with the mouse to rotate
, resolution 1.75Å
Sites:
Ligands:
Activity: Coagulation factor Xa, with EC number 3.4.21.6
Coordinates: save as pdb, mmCIF, xml



SELECTIVE AND DUAL ACTION ORALLY ACTIVE INHIBITORS OF THROMBIN AND FACTOR XA


Disease

Known disease associated with this structure: Factor X deficiency OMIM:[227600]

About this Structure

2UWO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Mar 20 18:40:45 2008

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