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Gyrase

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Line 28: Line 28:
*Gyrase Subunit B
*Gyrase Subunit B
-
**[[3g75]], [[3g7b]], [[3g7e]] – GyrB+thiazole inhibitor – ''Staphylococcus aureus''<br />
+
**[[3g75]], [[3g7b]], [[3g7e]], [[3ttz]], [[3u2d]], [[3u2k]], [[4p8o]] – GyrB+ inhibitor – ''Staphylococcus aureus''<br />
-
**[[3ttz]], [[3u2d]], [[3u2k]] – SaGyrB + pyrrolamide inhibitor<br />
+
**[[4urm]], [[4uro]] - SaGyrB N-terminal + antibiotic<br />
**[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br />
**[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br />
**[[3cwv]] – GyrB truncated – ''Myxococcus xanthus''<br />
**[[3cwv]] – GyrB truncated – ''Myxococcus xanthus''<br />
-
**[[1kzn]], [[1ei1]] - EcGyrB N-terminal+clorobiocin<br />
+
**[[4wub]], [[4wuc]], [[4wud]], [[4xtj]] - EcGyrB N-terminal<br />
-
**[[1aj6]] - EcGyrB N-terminal+novobiocin<br />
+
**[[1kzn]], [[1ei1]], [[1aj6]] - EcGyrB N-terminal+ antibiotic<br />
**[[4duh]] - EcGyrB N-terminal+ inhibitor<br />
**[[4duh]] - EcGyrB N-terminal+ inhibitor<br />
-
**[[4hyp]] - EcGyrB + inhibitor<br />
+
**[[4hyp]] - EcGyrB residues 15-220 + inhibitor<br />
-
**[[1kij]] – GyrB domain+novobiocin – ''Thermus thermophilus''<br />
+
**[[1kij]] – GyrB ATPase domain+ antibiotic – ''Thermus thermophilus''<br />
**[[4b6c]] - GyrB ATPase domain – ''Mycobacterium smegmatis''<br />
**[[4b6c]] - GyrB ATPase domain – ''Mycobacterium smegmatis''<br />
**[[4gee]], [[4gfn]], [[4ggl]], [[4hxw]], [[4k4o]], [[4kfg]], [[4ksg]], [[4ksh]], [[4ktn]] – GyrB + inhibitor – ''Enterococcus faecalis''<br />
**[[4gee]], [[4gfn]], [[4ggl]], [[4hxw]], [[4k4o]], [[4kfg]], [[4ksg]], [[4ksh]], [[4ktn]] – GyrB + inhibitor – ''Enterococcus faecalis''<br />
Line 45: Line 45:
*Gyrase Subunit A+Subunit B
*Gyrase Subunit A+Subunit B
-
**[[2xco]], [[2xcq]] - SaGyrB C-terminal-SaGyrA N-terminal fusion<br />
+
**[[2xco]], [[2xcq]] - SaGyrB C-terminal/SaGyrA N-terminal <br />
-
**[[2xcr]], [[2xcs]], [[4bul]] - SaGyrB C-terminal-SaGyrA N-terminal fusion (mutant)+DNA<br />
+
**[[4plb]] - SaGyrB C-terminal/SaGyrA N-terminal +DNA<br />
-
**[[2xct]] - SaGyrB C-terminal-SaGyrA N-terminal fusion (mutant) +DNA+ ciprofloxacin<br />
+
**[[2xcr]], [[2xcs]], [[4bul]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant)+DNA<br />
 +
**[[2xct]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant) +DNA+ antibiotic<br />
 +
**[[4tma]] - SaGyrB C-terminal- + SaGyrA N-terminal + Gyr inhibitor YACG<br />
**[[3nuh]] – EcGyrA+EcGyrB
**[[3nuh]] – EcGyrA+EcGyrB

Revision as of 09:24, 14 April 2015

Template:STRUCTURE 3uc1

Gyrase (Gyr) is a type of topoisomerase II in prokaryotes which unwinds double stranded DNA. The DNA Gyr cutting allows the formation of a negative DNA supercoil which enables replication of DNA. Gyr consists of 2 subunits: GyrA and GyrB. Reverse gyrase (Top-RG) is a type of topoisomerase I which catalyses the formation of positive DNA supercoil. [1]

3D Structure of Gyrase

Updated on 14-April-2015

Additional Resources

For additional information, see: Bacterial Infections

References

  1. ↑ Gore J, Bryant Z, Stone MD, Nollmann M, Cozzarelli NR, Bustamante C. Mechanochemical analysis of DNA gyrase using rotor bead tracking. Nature. 2006 Jan 5;439(7072):100-4. PMID:16397501 doi:10.1038/nature04319

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman

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