2v1c

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[[Image:2v1c.jpg|left|200px]]<br /><applet load="2v1c" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2v1c.jpg|left|200px]]
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caption="2v1c, resolution 3.80&Aring;" />
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'''CRYSTAL STRUCTURE AND MUTATIONAL STUDY OF RECOR PROVIDE INSIGHT INTO ITS ROLE IN DNA REPAIR'''<br />
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{{Structure
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|PDB= 2v1c |SIZE=350|CAPTION= <scene name='initialview01'>2v1c</scene>, resolution 3.80&Aring;
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+C'>AC1</scene>
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE AND MUTATIONAL STUDY OF RECOR PROVIDE INSIGHT INTO ITS ROLE IN DNA REPAIR'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2V1C is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+C'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V1C OCA].
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2V1C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V1C OCA].
==Reference==
==Reference==
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Crystal structure and mutational study of RecOR provide insight into its mode of DNA binding., Timmins J, Leiros I, McSweeney S, EMBO J. 2007 Jul 11;26(13):3260-71. Epub 2007 Jun 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17581636 17581636]
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Crystal structure and mutational study of RecOR provide insight into its mode of DNA binding., Timmins J, Leiros I, McSweeney S, EMBO J. 2007 Jul 11;26(13):3260-71. Epub 2007 Jun 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17581636 17581636]
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Timmins, J.]]
[[Category: Timmins, J.]]
[[Category: ZN]]
[[Category: ZN]]
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[[Category: deinococcus radiodurans]]
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[[Category: deinococcus radioduran]]
[[Category: dna binding]]
[[Category: dna binding]]
[[Category: dna damage]]
[[Category: dna damage]]
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[[Category: zinc-finger]]
[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:52:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:42:16 2008''

Revision as of 16:42, 20 March 2008

Image:2v1c.jpg


PDB ID 2v1c

Drag the structure with the mouse to rotate
, resolution 3.80Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE AND MUTATIONAL STUDY OF RECOR PROVIDE INSIGHT INTO ITS ROLE IN DNA REPAIR


Overview

The crystal structure of the complex formed between Deinococcus radiodurans RecR and RecO (drRecOR) has been determined. In accordance with previous biochemical characterisation, the drRecOR complex displays a RecR:RecO molecular ratio of 2:1. The biologically relevant drRecOR entity consists of a heterohexamer in the form of two drRecO molecules positioned on either side of the tetrameric ring of drRecR, with their OB (oligonucleotide/oligosaccharide-binding) domains pointing towards the interior of the ring. Mutagenesis studies validated the protein-protein interactions observed in the crystal structure and allowed mapping of the residues in the drRecOR complex required for DNA binding. Furthermore, the preferred DNA substrate of drRecOR was identified as being 3'-overhanging DNA, as encountered at ssDNA-dsDNA junctions. Together these results suggest a possible mechanism for drRecOR recognition of stalled replication forks.

About this Structure

2V1C is a Protein complex structure of sequences from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Crystal structure and mutational study of RecOR provide insight into its mode of DNA binding., Timmins J, Leiros I, McSweeney S, EMBO J. 2007 Jul 11;26(13):3260-71. Epub 2007 Jun 21. PMID:17581636

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