2v26

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[[Image:2v26.jpg|left|200px]]<br /><applet load="2v26" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2v26.jpg|left|200px]]
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caption="2v26, resolution 1.75&Aring;" />
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'''MYOSIN VI (MD) PRE-POWERSTROKE STATE (MG.ADP.VO4)'''<br />
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{{Structure
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|PDB= 2v26 |SIZE=350|CAPTION= <scene name='initialview01'>2v26</scene>, resolution 1.75&Aring;
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|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Vo4+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Edo+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Edo+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Edo+Binding+Site+For+Chain+A'>AC6</scene>, <scene name='pdbsite=AC7:Edo+Binding+Site+For+Chain+A'>AC7</scene>, <scene name='pdbsite=AC8:Edo+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=AC9:Edo+Binding+Site+For+Chain+A'>AC9</scene>, <scene name='pdbsite=BC1:Edo+Binding+Site+For+Chain+A'>BC1</scene>, <scene name='pdbsite=BC2:So4+Binding+Site+For+Chain+A'>BC2</scene> and <scene name='pdbsite=BC3:So4+Binding+Site+For+Chain+A'>BC3</scene>
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|LIGAND= <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''MYOSIN VI (MD) PRE-POWERSTROKE STATE (MG.ADP.VO4)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2V26 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=VO4:'>VO4</scene>, <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=ADP:'>ADP</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Vo4+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Edo+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Edo+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Edo+Binding+Site+For+Chain+A'>AC6</scene>, <scene name='pdbsite=AC7:Edo+Binding+Site+For+Chain+A'>AC7</scene>, <scene name='pdbsite=AC8:Edo+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=AC9:Edo+Binding+Site+For+Chain+A'>AC9</scene>, <scene name='pdbsite=BC1:Edo+Binding+Site+For+Chain+A'>BC1</scene>, <scene name='pdbsite=BC2:So4+Binding+Site+For+Chain+A'>BC2</scene> and <scene name='pdbsite=BC3:So4+Binding+Site+For+Chain+A'>BC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V26 OCA].
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2V26 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V26 OCA].
==Reference==
==Reference==
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The structural basis for the large powerstroke of myosin VI., Menetrey J, Llinas P, Mukherjea M, Sweeney HL, Houdusse A, Cell. 2007 Oct 19;131(2):300-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17956731 17956731]
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The structural basis for the large powerstroke of myosin VI., Menetrey J, Llinas P, Mukherjea M, Sweeney HL, Houdusse A, Cell. 2007 Oct 19;131(2):300-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17956731 17956731]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: vanadate]]
[[Category: vanadate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:52:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:42:34 2008''

Revision as of 16:42, 20 March 2008

Image:2v26.jpg


PDB ID 2v26

Drag the structure with the mouse to rotate
, resolution 1.75Å
Sites: , , , , , , , , , , and
Ligands: , , , and
Coordinates: save as pdb, mmCIF, xml



MYOSIN VI (MD) PRE-POWERSTROKE STATE (MG.ADP.VO4)


Overview

Due to a unique addition to the lever arm-positioning region (converter), class VI myosins move in the opposite direction (toward the minus-end of actin filaments) compared to other characterized myosin classes. However, the large size of the myosin VI lever arm swing (powerstroke) cannot be explained by our current view of the structural transitions that occur within the myosin motor. We have solved the crystal structure of a fragment of the myosin VI motor in the structural state that represents the starting point for movement on actin; the pre-powerstroke state. Unexpectedly, the converter itself rearranges to achieve a conformation that has not been seen for other myosins. This results in a much larger powerstroke than is achievable without the converter rearrangement. Moreover, it provides a new mechanism that could be exploited to increase the powerstroke of yet to be characterized plus-end-directed myosin classes.

About this Structure

2V26 is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

The structural basis for the large powerstroke of myosin VI., Menetrey J, Llinas P, Mukherjea M, Sweeney HL, Houdusse A, Cell. 2007 Oct 19;131(2):300-8. PMID:17956731

Page seeded by OCA on Thu Mar 20 18:42:34 2008

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