4wdw

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'''Unreleased structure'''
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==17beta-HSD5 in complex with 3,6-dihydropyridin-1(2H)-yl(5-methyl-1H-indol-2-yl)methanone==
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<StructureSection load='4wdw' size='340' side='right' caption='[[4wdw]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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The entry 4wdw is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4wdw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WDW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WDW FirstGlance]. <br>
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Authors: Amano, Y., Yamaguchi, T.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=WDW:3,6-DIHYDROPYRIDIN-1(2H)-YL(5-METHYL-1H-INDOL-2-YL)METHANONE'>WDW</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wds|4wds]], [[4wdt|4wdt]], [[4wdu|4wdu]], [[4wdv|4wdv]], [[4wdx|4wdx]]</td></tr>
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Description: 17beta-HSD5 in complex with 3,6-dihydropyridin-1(2H)-yl(5-methyl-1H-indol-2-yl)methanone
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Testosterone_17-beta-dehydrogenase_(NADP(+)) Testosterone 17-beta-dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.64 1.1.1.64] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wdw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wdw RCSB], [http://www.ebi.ac.uk/pdbsum/4wdw PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
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__TOC__
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</StructureSection>
[[Category: Amano, Y]]
[[Category: Amano, Y]]
[[Category: Yamaguchi, T]]
[[Category: Yamaguchi, T]]
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[[Category: Aldo-keto reductase inhibitor]]

Revision as of 13:02, 15 April 2015

17beta-HSD5 in complex with 3,6-dihydropyridin-1(2H)-yl(5-methyl-1H-indol-2-yl)methanone

4wdw, resolution 1.94Å

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