Sandbox Reserved 978

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
{{Telford_CHEM321}}<!-- HI DR. T!!!!!!!!! -->
{{Telford_CHEM321}}<!-- HI DR. T!!!!!!!!! -->
==Thioredoxin Reductase==
==Thioredoxin Reductase==
-
The protein Thioredoxin Reductase (TrxR) is utilized in the regulation of DNA translation and in apoptosis. A normal stop codon (UGA, UAA, and UAG) stops the translation of the mRNA, but in the presence of TrxR an extra Selenocysteine is added to the end of the protein chain. This extra amino acid is what marks the structure for death inside the cell. Enough of these structures in the cell and the entire cell will undergo apoptosis.
+
 
<StructureSection load='2zbw' size='340' side='right' caption='Thioredoxin Reductase=''>
<StructureSection load='2zbw' size='340' side='right' caption='Thioredoxin Reductase=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
Line 7: Line 7:
== Function ==
== Function ==
-
 
+
The protein Thioredoxin Reductase (TrxR) is utilized in the regulation of DNA translation and in apoptosis. A normal stop codon (UGA, UAA, and UAG) stops the translation of the mRNA, but in the presence of TrxR an extra Selenocysteine is added to the end of the protein chain. This extra amino acid is what marks the structure for death inside the cell. Enough of these structures in the cell and the entire cell will undergo apoptosis.
== Disease ==
== Disease ==
When left unregulated cell death does not perform as functioned resulting in a build-up of tissue and most often the cause of tumorous growths in the body. This includes cancerous growths as well as non-cancerous.
When left unregulated cell death does not perform as functioned resulting in a build-up of tissue and most often the cause of tumorous growths in the body. This includes cancerous growths as well as non-cancerous.

Revision as of 13:10, 16 April 2015

This Sandbox is Reserved from 15-Jan-2015, through 30-May-2015 for use in the course "Biochemistry" taught by Jason Telford at the Maryville University. This reservation includes Sandbox Reserved 977 through Sandbox Reserved 986.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Thioredoxin Reductase

PDB ID 2zbw

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_978"
Personal tools