Hirudin
From Proteopedia
(Difference between revisions)
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* Hirugen + Thrombin light and heavy chains | * Hirugen + Thrombin light and heavy chains | ||
| - | **[[2zhe]], [[2zhf]], [[2zhw]], [[2zg0]], [[2zfq]], [[2zfr]], [[1c5l]], [[1hxf]], [[1hah]], [[1hai]], [[1abi]], [[1abj]], [[1hgt]], [[2uuf]], [[1aix]], [[1ay6]], [[1awf]], [[2hgt] - Hirg+ hThr L&H chains<br /> | + | **[[2zhe]], [[2zhf]], [[2zhw]], [[2zg0]], [[2zfq]], [[2zfr]], [[1c5l]], [[1hxf]], [[1hah]], [[1hai]], [[1abi]], [[1abj]], [[1hgt]], [[2uuf]], [[1aix]], [[1ay6]], [[1awf]], [[2hgt]] - Hirg+ hThr L&H chains<br /> |
* Hirugen + prothrombin | * Hirugen + prothrombin | ||
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**[[2feq]], [[2fes]] – Hirg analog + hThr L&H chains+inhibitor<br /> | **[[2feq]], [[2fes]] – Hirg analog + hThr L&H chains+inhibitor<br /> | ||
**[[3sha]], [[3shc]], [[3si3]], [[3si4]], [[3sv2]], [[3t5f]], [[3u98]], [[3u9a]], [[3uwj]], [[4ban]], [[4bao]], [[4e7r]], [[4loy]] – Hirg variant 2 + hThr L&H chains+inhibitor<br /> | **[[3sha]], [[3shc]], [[3si3]], [[3si4]], [[3sv2]], [[3t5f]], [[3u98]], [[3u9a]], [[3uwj]], [[4ban]], [[4bao]], [[4e7r]], [[4loy]] – Hirg variant 2 + hThr L&H chains+inhibitor<br /> | ||
| - | **[[4bah]], [[4bak]], [[4bam]], [[4baq]], [[4lxb, [[4mlf | + | **[[4bah]], [[4bak]], [[4bam]], [[4baq]], [[4lxb]], [[4mlf]] – Hirg variant 1 + hThr L&H chains+inhibitor<br /> |
* Hirugen+Thrombin light and heavy chains+ protein | * Hirugen+Thrombin light and heavy chains+ protein | ||
Revision as of 08:04, 21 April 2015
Hirudin (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts fibrinogen to fibrin upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). Hirugen (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). The image at the right correspond to one representative Hirudin, i.e. the NMR Structure of Hirudin (1hic). For additional details see Sean Swale/Human Thrombin Inhibitor.
3D Structures of Hirudin
Updated on 21-April-2015
