Histone methyltransferase
From Proteopedia
(Difference between revisions)
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**[[3s8s]] – hKHMT SETD1A RRM domain<br /> | **[[3s8s]] – hKHMT SETD1A RRM domain<br /> | ||
| + | **[[2mdc]], [[2mdj]] - hKHMT SETD2 WW domain - NMR<br /> | ||
| + | **[[2mdi]] - hKHMT SETD2 WW domain (mutant) - NMR<br /> | ||
**[[2r3a]] – hKHMT Suv39H2<br /> | **[[2r3a]] – hKHMT Suv39H2<br /> | ||
**[[3rq4]] - hKHMT Suv420H2<br /> | **[[3rq4]] - hKHMT Suv420H2<br /> | ||
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**[[2kyu]] - hKHMT Mll Phd3 finger – NMR<br /> | **[[2kyu]] - hKHMT Mll Phd3 finger – NMR<br /> | ||
**[[4gnd]] - hKHMT Nsd3 Phd5-C5HCH<br /> | **[[4gnd]] - hKHMT Nsd3 Phd5-C5HCH<br /> | ||
| + | **[[4rxj]] - hKHMT Nsd3 residues 953-1064<br /> | ||
| + | **[[4yz8]] - hKHMT Nsd3 residues 1054-1285<br /> | ||
**[[3lqh]] - hKHMT Mll Phd bromodomain<br /> | **[[3lqh]] - hKHMT Mll Phd bromodomain<br /> | ||
**[[3b7b]] - hKHMT ankyrin repeat domains 2-7<br /> | **[[3b7b]] - hKHMT ankyrin repeat domains 2-7<br /> | ||
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**[[3rib]] – hKHMT Smyd2 + SAH<br /> | **[[3rib]] – hKHMT Smyd2 + SAH<br /> | ||
**[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | **[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br /> | ||
| + | **[[4wuy]] - hKHMT Smyd2 + inhibitor<br /> | ||
**[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br /> | **[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br /> | ||
**[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br /> | **[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br /> | ||
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**[[2v74]], [[2v7e]] – mRHMT catalytic domain <br /> | **[[2v74]], [[2v7e]] – mRHMT catalytic domain <br /> | ||
| + | **[[4c03]], [[4c06]], [[4c07]], [[4c08]] – mRHMT 6<br /> | ||
| + | **[[4c04]] – mRHMT 6 + inhibitor<br /> | ||
| + | **[[4c05]] – mRHMT 6 + SAH<br /> | ||
| + | **[[4c4a]] – mRHMT 7 + SAH<br /> | ||
**[[2obq]] – rRHMT N terminal - rat <br /> | **[[2obq]] – rRHMT N terminal - rat <br /> | ||
**[[3b3g]], [[3b3j]] – rRHMT catalytic domain <br /> | **[[3b3g]], [[3b3j]] – rRHMT catalytic domain <br /> | ||
**[[3b3f]] – rRHMT catalytic domain + SAH<br /> | **[[3b3f]] – rRHMT catalytic domain + SAH<br /> | ||
| - | **[[2y1w]], [[2y1x]] – hRHMT catalytic domain + sinefungin + indole inhibitor<br /> | + | **[[2y1w]], [[2y1x]] – hRHMT 4 catalytic domain + sinefungin + indole inhibitor<br /> |
| - | **[[4ikp]] – hRHMT catalytic domain + purine derivative<br /> | + | **[[4ikp]] – hRHMT 4 catalytic domain + purine derivative<br /> |
| + | **[[4gqb]] – hRHMT 5 + methylsome protein 50 + H4 peptide<br /> | ||
| + | **[[4qqk]] – hRHMT 6 <br /> | ||
| + | **[[4hc4]] – hRHMT 6 (mutant)<br /> | ||
| + | **[[4qpp]] – hRHMT 6 (mutant) + peptide + inhibitor<br /> | ||
| + | |||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:11, 21 April 2015
Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. CxxC domain is a zinc finger domain.
3D Structures of histone methyltransferase
Updated on 21-April-2015
