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2vb2

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[[Image:2vb2.jpg|left|200px]]<br /><applet load="2vb2" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2vb2.jpg|left|200px]]
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caption="2vb2, resolution 1.70&Aring;" />
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'''CRYSTAL STRUCTURE OF CU(I)CUSF'''<br />
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{{Structure
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|PDB= 2vb2 |SIZE=350|CAPTION= <scene name='initialview01'>2vb2</scene>, resolution 1.70&Aring;
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+X'>AC1</scene> and <scene name='pdbsite=AC2:Cu+Binding+Site+For+Chain+X'>AC2</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=CU:COPPER (II) ION'>CU</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF CU(I)CUSF'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2VB2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=CU:'>CU</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+X'>AC1</scene> and <scene name='pdbsite=AC2:Cu+Binding+Site+For+Chain+X'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB2 OCA].
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2VB2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB2 OCA].
==Reference==
==Reference==
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Cu(I) recognition via cation-pi and methionine interactions in CusF., Xue Y, Davis AV, Balakrishnan G, Stasser JP, Staehlin BM, Focia P, Spiro TG, Penner-Hahn JE, O'Halloran TV, Nat Chem Biol. 2008 Feb;4(2):107-9. Epub 2007 Dec 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18157124 18157124]
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Cu(I) recognition via cation-pi and methionine interactions in CusF., Xue Y, Davis AV, Balakrishnan G, Stasser JP, Staehlin BM, Focia P, Spiro TG, Penner-Hahn JE, O'Halloran TV, Nat Chem Biol. 2008 Feb;4(2):107-9. Epub 2007 Dec 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18157124 18157124]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: periplasm]]
[[Category: periplasm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:54:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:45:05 2008''

Revision as of 16:45, 20 March 2008

Image:2vb2.jpg


PDB ID 2vb2

Drag the structure with the mouse to rotate
, resolution 1.70Å
Sites: and
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF CU(I)CUSF


Overview

Methionine-rich motifs have an important role in copper trafficking factors, including the CusF protein. Here we show that CusF uses a new metal recognition site wherein Cu(I) is tetragonally displaced from a Met2His ligand plane toward a conserved tryptophan. Spectroscopic studies demonstrate that both thioether ligation and strong cation-pi interactions with tryptophan stabilize metal binding. This novel active site chemistry affords mechanisms for control of adventitious metal redox and substitution chemistry.

About this Structure

2VB2 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Cu(I) recognition via cation-pi and methionine interactions in CusF., Xue Y, Davis AV, Balakrishnan G, Stasser JP, Staehlin BM, Focia P, Spiro TG, Penner-Hahn JE, O'Halloran TV, Nat Chem Biol. 2008 Feb;4(2):107-9. Epub 2007 Dec 23. PMID:18157124

Page seeded by OCA on Thu Mar 20 18:45:05 2008

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