2vcg
From Proteopedia
(Difference between revisions)
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| - | [[Image:2vcg.jpg|left|200px]] | + | [[Image:2vcg.jpg|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17''' | + | {{Structure |
| + | |PDB= 2vcg |SIZE=350|CAPTION= <scene name='initialview01'>2vcg</scene>, resolution 1.90Å | ||
| + | |SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+D'>AC1</scene>, <scene name='pdbsite=AC2:Gol+Binding+Site+For+Chain+C'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Chain+C'>AC5</scene>, <scene name='pdbsite=AC6:Zn+Binding+Site+For+Chain+D'>AC6</scene>, <scene name='pdbsite=AC7:Zn+Binding+Site+For+Chain+D'>AC7</scene>, <scene name='pdbsite=AC8:K+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=AC9:K+Binding+Site+For+Chain+B'>AC9</scene>, <scene name='pdbsite=BC1:K+Binding+Site+For+Chain+C'>BC1</scene>, <scene name='pdbsite=BC2:K+Binding+Site+For+Chain+D'>BC2</scene>, <scene name='pdbsite=BC3:K+Binding+Site+For+Chain+A'>BC3</scene>, <scene name='pdbsite=BC4:K+Binding+Site+For+Chain+B'>BC4</scene>, <scene name='pdbsite=BC5:K+Binding+Site+For+Chain+C'>BC5</scene>, <scene name='pdbsite=BC6:K+Binding+Site+For+Chain+D'>BC6</scene>, <scene name='pdbsite=BC7:S17+Binding+Site+For+Chain+D'>BC7</scene>, <scene name='pdbsite=BC8:S17+Binding+Site+For+Chain+C'>BC8</scene>, <scene name='pdbsite=BC9:S17+Binding+Site+For+Chain+A'>BC9</scene>, <scene name='pdbsite=CC1:S17+Binding+Site+For+Chain+B'>CC1</scene> and <scene name='pdbsite=CC2:Cl+Binding+Site+For+Chain+D'>CC2</scene> | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=S17:'>S17</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2VCG is a [ | + | 2VCG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. |
==Reference== | ==Reference== | ||
| - | Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Schafer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M, Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. Epub 2007 Nov 4. PMID:[http:// | + | Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Schafer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M, Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. Epub 2007 Nov 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18054239 18054239] |
[[Category: Alcaligenes sp.]] | [[Category: Alcaligenes sp.]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: inhibitor]] | [[Category: inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:45:25 2008'' |
Revision as of 16:45, 20 March 2008
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| , resolution 1.90Å | |||||||
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| Sites: | , , , , , , , , , , , , , , , , , , and | ||||||
| Ligands: | , , , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17
Overview
We synthesized biarylalanine-containing hydroxamic acids and tested them on immunoprecipitated HDAC1 and HDAC6 and show a subtype selectivity for HDAC6 that was confirmed in cells by Western blot (tubulin vs histones). We obtained an X-ray structure with a HDAC6-selective inhibitor with the bacterial deacetylase HDAH. Docking studies were carried out using HDAC1 and HDAC6 protein models. Antiproliferative activity was shown on cancer cells for selected compounds.
About this Structure
2VCG is a Single protein structure of sequence from Alcaligenes sp.. Full crystallographic information is available from OCA.
Reference
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Schafer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M, Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. Epub 2007 Nov 4. PMID:18054239
Page seeded by OCA on Thu Mar 20 18:45:25 2008
Categories: Alcaligenes sp. | Single protein | Dickmanns, A. | Ficner, R. | Strasser, A. | CL | GOL | K | S17 | ZN | Hdac-like amidohydrolase | Hdah | Histone deacetylase-like amidohydrolase | Hydrolase | Inhibitor
