4ofh
From Proteopedia
(Difference between revisions)
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| - | + | ==Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis== | |
| - | + | <StructureSection load='4ofh' size='340' side='right' caption='[[4ofh]], [[Resolution|resolution]] 2.22Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ofh]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OFH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OFH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iho|3iho]], [[4ea5|4ea5]], [[4e9g|4e9g]], [[4e9e|4e9e]], [[4e9f|4e9f]], [[4ea4|4ea4]], [[4ofa|4ofa]], [[4ofe|4ofe]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ofh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ofh RCSB], [http://www.ebi.ac.uk/pdbsum/4ofh PDBsum]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN]] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Lee, S]] | [[Category: Lee, S]] | ||
| + | [[Category: Lin, Y L]] | ||
| + | [[Category: Ouzon-Shubeita, H]] | ||
| + | [[Category: Hydrolase-dna complex]] | ||
| + | [[Category: Mismatch]] | ||
| + | [[Category: Protein-dna complex]] | ||
| + | [[Category: Thymine glycosylase]] | ||
Revision as of 12:51, 22 April 2015
Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis
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