2vee

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[[Image:2vee.jpg|left|200px]]<br /><applet load="2vee" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2vee.jpg|left|200px]]
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caption="2vee, resolution 2.60&Aring;" />
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'''STRUCTURE OF PROTOGLOBIN FROM METHANOSARCINA ACETIVORANS C2A'''<br />
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{{Structure
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|PDB= 2vee |SIZE=350|CAPTION= <scene name='initialview01'>2vee</scene>, resolution 2.60&Aring;
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|SITE= <scene name='pdbsite=AC1:Hem+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Hem+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:Hem+Binding+Site+For+Chain+C'>AC3</scene>, <scene name='pdbsite=AC4:Hem+Binding+Site+For+Chain+D'>AC4</scene>, <scene name='pdbsite=AC5:Hem+Binding+Site+For+Chain+E'>AC5</scene>, <scene name='pdbsite=AC6:Hem+Binding+Site+For+Chain+F'>AC6</scene>, <scene name='pdbsite=AC7:Hem+Binding+Site+For+Chain+G'>AC7</scene> and <scene name='pdbsite=AC8:Hem+Binding+Site+For+Chain+H'>AC8</scene>
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF PROTOGLOBIN FROM METHANOSARCINA ACETIVORANS C2A'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2VEE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans] with <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:Hem+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Hem+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:Hem+Binding+Site+For+Chain+C'>AC3</scene>, <scene name='pdbsite=AC4:Hem+Binding+Site+For+Chain+D'>AC4</scene>, <scene name='pdbsite=AC5:Hem+Binding+Site+For+Chain+E'>AC5</scene>, <scene name='pdbsite=AC6:Hem+Binding+Site+For+Chain+F'>AC6</scene>, <scene name='pdbsite=AC7:Hem+Binding+Site+For+Chain+G'>AC7</scene> and <scene name='pdbsite=AC8:Hem+Binding+Site+For+Chain+H'>AC8</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEE OCA].
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2VEE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEE OCA].
==Reference==
==Reference==
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Archaeal protoglobin structure indicates new ligand diffusion paths and modulation of haem-reactivity., Nardini M, Pesce A, Thijs L, Saito JA, Dewilde S, Alam M, Ascenzi P, Coletta M, Ciaccio C, Moens L, Bolognesi M, EMBO Rep. 2008 Feb;9(2):157-63. Epub 2008 Jan 11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18188182 18188182]
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Archaeal protoglobin structure indicates new ligand diffusion paths and modulation of haem-reactivity., Nardini M, Pesce A, Thijs L, Saito JA, Dewilde S, Alam M, Ascenzi P, Coletta M, Ciaccio C, Moens L, Bolognesi M, EMBO Rep. 2008 Feb;9(2):157-63. Epub 2008 Jan 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18188182 18188182]
[[Category: Methanosarcina acetivorans]]
[[Category: Methanosarcina acetivorans]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: hemoprotein structure]]
[[Category: hemoprotein structure]]
[[Category: methanogenesis]]
[[Category: methanogenesis]]
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[[Category: protein matrix tunnels]]
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[[Category: protein matrix tunnel]]
[[Category: protoglobin]]
[[Category: protoglobin]]
[[Category: transport protein]]
[[Category: transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:55:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:45:41 2008''

Revision as of 16:45, 20 March 2008

Image:2vee.jpg


PDB ID 2vee

Drag the structure with the mouse to rotate
, resolution 2.60Å
Sites: , , , , , , and
Ligands:
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF PROTOGLOBIN FROM METHANOSARCINA ACETIVORANS C2A


Overview

The structural adaptability of the globin fold has been highlighted by the recent discovery of the 2-on-2 haemoglobins, of neuroglobin and cytoglobin. Protoglobin from Methanosarcina acetivorans C2A-a strictly anaerobic methanogenic Archaea-is, to the best of our knowledge, the latest entry adding new variability and functional complexity to the haemoglobin (Hb) superfamily. Here, we report the 1.3 A crystal structure of oxygenated M. acetivorans protoglobin, together with the first insight into its ligand-binding properties. We show that, contrary to all known globins, protoglobin-specific loops and an amino-terminal extension completely bury the haem within the protein matrix. Access of O(2), CO and NO to the haem is granted by the protoglobin-specific apolar tunnels reaching the haem distal site from locations at the B/G and B/E helix interfaces. Functionally, M. acetivorans dimeric protoglobin shows a selectivity ratio for O(2)/CO binding to the haem that favours O(2) ligation and anticooperativity in ligand binding. Both properties are exceptional within the Hb superfamily.

About this Structure

2VEE is a Single protein structure of sequence from Methanosarcina acetivorans. Full crystallographic information is available from OCA.

Reference

Archaeal protoglobin structure indicates new ligand diffusion paths and modulation of haem-reactivity., Nardini M, Pesce A, Thijs L, Saito JA, Dewilde S, Alam M, Ascenzi P, Coletta M, Ciaccio C, Moens L, Bolognesi M, EMBO Rep. 2008 Feb;9(2):157-63. Epub 2008 Jan 11. PMID:18188182

Page seeded by OCA on Thu Mar 20 18:45:41 2008

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