4pcr

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'''Unreleased structure'''
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==Crystal structure of Canavalia brasiliensis seed lectin (ConBr) complexed with Gamma-Aminobutyric Acid (GABA)==
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<StructureSection load='4pcr' size='340' side='right' caption='[[4pcr]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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The entry 4pcr is ON HOLD until Apr 19 2016
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4pcr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_brasiliensis Canavalia brasiliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PCR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PCR FirstGlance]. <br>
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Authors: Delatorre, P., Rocha, B.A.M., Silva-Filho, J.C., Teixeira, C.S., Cavada, B.S., Nascimento, K.S., Nbrega, R.B., Nagano, C.S., Sampaio, A.H., Leal, R.B., Neto, I.L.B.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i30|4i30]]</td></tr>
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Description: Crystal structure of Canavalia brasiliensis seed lectin (ConBr) complexed with Gamma-Aminobutyric Acid (GABA)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pcr RCSB], [http://www.ebi.ac.uk/pdbsum/4pcr PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Nascimento, K.S]]
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== Function ==
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[[Category: Teixeira, C.S]]
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[[http://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR]] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
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[[Category: Silva-Filho, J.C]]
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== References ==
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[[Category: Neto, I.L.B]]
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<references/>
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[[Category: Nbrega, R.B]]
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__TOC__
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[[Category: Cavada, B.S]]
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</StructureSection>
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[[Category: Rocha, B.A.M]]
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[[Category: Canavalia brasiliensis]]
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[[Category: Leal, R.B]]
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[[Category: Cavada, B S]]
[[Category: Delatorre, P]]
[[Category: Delatorre, P]]
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[[Category: Sampaio, A.H]]
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[[Category: Leal, R B]]
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[[Category: Nagano, C.S]]
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[[Category: Nagano, C S]]
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[[Category: Nascimento, K S]]
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[[Category: Nbrega, R B]]
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[[Category: Neto, I L.B]]
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[[Category: Rocha, B A.M]]
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[[Category: Sampaio, A H]]
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[[Category: Silva-Filho, J C]]
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[[Category: Teixeira, C S]]
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[[Category: Sugar binding protein]]

Revision as of 12:51, 22 April 2015

Crystal structure of Canavalia brasiliensis seed lectin (ConBr) complexed with Gamma-Aminobutyric Acid (GABA)

4pcr, resolution 2.15Å

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