4xq7

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m (Protected "4xq7" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==The crystal structure of the OAS-like domain (OLD) of human OASL==
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<StructureSection load='4xq7' size='340' side='right' caption='[[4xq7]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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The entry 4xq7 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4xq7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQ7 FirstGlance]. <br>
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Authors: Ibsen, M.S., Gad, H.H., Andersen, L.L., Hornung, V., Julkunen, I., Sarkar, S.N., Hartmann, R.
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4xq7 PDBsum]</span></td></tr>
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Description: OAS-like domain of OASL (OASL (1-350))
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Gad, H.H]]
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[[http://www.uniprot.org/uniprot/OASL_HUMAN OASL_HUMAN]] Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.<ref>PMID:9826176</ref> <ref>PMID:18931074</ref> <ref>PMID:20074559</ref>
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[[Category: Hornung, V]]
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== References ==
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[[Category: Ibsen, M.S]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Andersen, L L]]
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[[Category: Gad, H H]]
[[Category: Hartmann, R]]
[[Category: Hartmann, R]]
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[[Category: Sarkar, S.N]]
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[[Category: Hornung, V]]
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[[Category: Ibsen, M S]]
[[Category: Julkunen, I]]
[[Category: Julkunen, I]]
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[[Category: Andersen, L.L]]
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[[Category: Sarkar, S N]]
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[[Category: 2'-5' oligoadenylate synthetase]]
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[[Category: Oa]]
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[[Category: Oasl]]
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[[Category: Oligoadenylate synthetase]]
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[[Category: Oligoadenylate synthetase-like]]
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[[Category: Transferase]]

Revision as of 12:54, 22 April 2015

The crystal structure of the OAS-like domain (OLD) of human OASL

4xq7, resolution 1.60Å

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