This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Interleukin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 11: Line 11:
* '''IL-8''' induces chemotaxis and phagocytosis.<br />
* '''IL-8''' induces chemotaxis and phagocytosis.<br />
* '''IL-10''' see [[Interleukin-10]].<br />
* '''IL-10''' see [[Interleukin-10]].<br />
-
*''' IL-12''' induces the differentiation of naive helper T cells (Th0) to Th1 cells.<br />
+
* '''IL-11''' involved in the stimulation of megakaryocyte maturation.<br />
 +
* ''' IL-12''' induces the differentiation of naive helper T cells (Th0) to Th1 cells.<br />
* '''IL-13''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br />
* '''IL-13''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br />
* '''IL-15''' see [[Interleukin-15]].<br />
* '''IL-15''' see [[Interleukin-15]].<br />
Line 18: Line 19:
* '''IL-18''' induces cell-mediated immunity following infection by microbial lipopolysaccharides.<br />
* '''IL-18''' induces cell-mediated immunity following infection by microbial lipopolysaccharides.<br />
* '''IL-19''' induces activation of the signal transducer and activator of STAT3.<br />
* '''IL-19''' induces activation of the signal transducer and activator of STAT3.<br />
-
*''' IL-21''' has potent effect on natural killer cells.<br />
+
* ''' IL-21''' has potent effect on natural killer cells.<br />
* '''IL-22''' stimulates inflammatory responses like S100 and defensin.<br />
* '''IL-22''' stimulates inflammatory responses like S100 and defensin.<br />
-
*''' IL-23''' induces activation of the signal transducer and activator of STAT4.<br />
+
* ''' IL-23''' induces activation of the signal transducer and activator of STAT4.<br />
* '''IL-28''' has a role in the immune defense against viruses.<br />
* '''IL-28''' has a role in the immune defense against viruses.<br />
* '''IL-29''' similar to IL-28.<br />
* '''IL-29''' similar to IL-28.<br />
* '''IL-33''' induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.<br />
* '''IL-33''' induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.<br />
* '''IL-34''' increases growth or survival of monocytes.<br />
* '''IL-34''' increases growth or survival of monocytes.<br />
-
+
* '''IL-36''' acts on naïve CD4+ T cells.
 +
 
==3D structures of interleukin==
==3D structures of interleukin==
Line 64: Line 66:
**[[1qvn]], [[1nbp]], [[1m4a]], [[1m4b]] – hIL-2 (mutant) + inhibitor<BR />
**[[1qvn]], [[1nbp]], [[1m4a]], [[1m4b]] – hIL-2 (mutant) + inhibitor<BR />
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
 +
**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />
*IL-3
*IL-3
Line 78: Line 81:
**[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR />
**[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR />
**[[3qb7]] - hIL-4 + cytokine receptor common γ<BR />
**[[3qb7]] - hIL-4 + cytokine receptor common γ<BR />
 +
**[[4ydy]] – hIL-4 + darpin<BR />
**[[3bpn]] - hIL-4 + IL-4 receptor α + IL-13 receptor α
**[[3bpn]] - hIL-4 + IL-4 receptor α + IL-13 receptor α
Line 96: Line 100:
**[[4j4l]] – hIL-6 + internalin B<BR />
**[[4j4l]] – hIL-6 + internalin B<BR />
**[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR />
**[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR />
 +
**[[4cni]], [[4o9h]] – hIL-6 + antibody<BR />
*IL-7
*IL-7
Line 113: Line 118:
**[[2h24]], [[1inr]], [[2ilk]], [[1ilk]] – hIL-10<BR />
**[[2h24]], [[1inr]], [[2ilk]], [[1ilk]] – hIL-10<BR />
 +
**[[4x51]] – mIL-10<BR />
**[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) <BR />
**[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) <BR />
**[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α
**[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α
Line 123: Line 129:
**[[1lqs]] - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5<BR />
**[[1lqs]] - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5<BR />
**[[1lk3]] - hvIL-10 residues 26-175 + antibody
**[[1lk3]] - hvIL-10 residues 26-175 + antibody
 +
 +
*IL-11
 +
 +
**[[4mhl]] - hIL-11<br />
*IL-12
*IL-12
Line 129: Line 139:
**[[1f42]] - hIL-12 β P40 domain<BR />
**[[1f42]] - hIL-12 β P40 domain<BR />
**[[3hmx]] - hIL-12 α and β+ antibody<br />
**[[3hmx]] - hIL-12 α and β+ antibody<br />
 +
**[[4oe8]], [[4og9]] - hIL-12 β + hIL-23 α + alphabody MB3<br />
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin
Line 160: Line 171:
*IL-18 (Interferon-γ inducing factor)
*IL-18 (Interferon-γ inducing factor)
 +
**[[3wo2]] – hIL-18 <BR />
**[[1j0s]] – hIL-18 - NMR<BR />
**[[1j0s]] – hIL-18 - NMR<BR />
**[[4hjj]] - hIL-18 + antibody<br />
**[[4hjj]] - hIL-18 + antibody<br />
**[[2vxt]] - hIL-18 (mutant) + antibody<BR />
**[[2vxt]] - hIL-18 (mutant) + antibody<BR />
**[[3f62]] - hIL-18 residues 37-193 (mutant) + IL-18 binding protein<br />
**[[3f62]] - hIL-18 residues 37-193 (mutant) + IL-18 binding protein<br />
-
**[[4eee]], [[4ekx]] - hIL-18 (mutant) + 14L protein
+
**[[4eee]], [[4ekx]] - hIL-18 (mutant) + 14L protein<br />
 +
**[[3wo3]], [[4r6u]] - hIL-18 + IL-18 receptor<br />
 +
**[[3wo4]] - hIL-18 + IL-18 receptor + IL-18 receptor accessory protein<br />
*IL-19
*IL-19
Line 182: Line 196:
**[[1ykb]], [[1m4r]] – hIL-22<BR />
**[[1ykb]], [[1m4r]] – hIL-22<BR />
 +
**[[4ok6]] – IL-22 – zebra fish<BR />
**[[3g9v]] - hIL-22 residues 29-179 + IL-22 receptor α2<BR />
**[[3g9v]] - hIL-22 residues 29-179 + IL-22 receptor α2<BR />
**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />
**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />
Line 212: Line 227:
**[[4exp]] - mIL-34 active core + macrophage colony-stimulating factor 1 receptor<br />
**[[4exp]] - mIL-34 active core + macrophage colony-stimulating factor 1 receptor<br />
**[[4dke]], [[4dkf]] - hIL-34 active core + antibody
**[[4dke]], [[4dkf]] - hIL-34 active core + antibody
 +
 +
*IL-36
 +
 +
**[[4ize]] - hIL-36 γ<br />
 +
}}
}}
[[Category: Topic Page]]
[[Category: Topic Page]]

Revision as of 08:19, 28 April 2015

Template:STRUCTURE 2nvh

Interleukin (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers.

  • IL-1 is a group of 11 cytokines which regulate immune and inflammatory response. See Interleukin-1 beta.
  • IL-2 is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.
  • IL-3 improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.
  • IL-4 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
  • IL-5 stimulates B cell growth and increases immunoglobulin secretion.
  • IL-6 is both a pro-inflammatory cytokine and anti-inflammatory myokine.
  • IL-7 is a cytokine important for B and T cells development.
  • IL-8 induces chemotaxis and phagocytosis.
  • IL-10 see Interleukin-10.
  • IL-11 involved in the stimulation of megakaryocyte maturation.
  • IL-12 induces the differentiation of naive helper T cells (Th0) to Th1 cells.
  • IL-13 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
  • IL-15 see Interleukin-15.
  • IL-16 acts as chemoattractant, modulator of T cell activity and inhibitor of HIV replication.
  • IL-17 recruits monocytes and neutrophils to the site of inflammation.
  • IL-18 induces cell-mediated immunity following infection by microbial lipopolysaccharides.
  • IL-19 induces activation of the signal transducer and activator of STAT3.
  • IL-21 has potent effect on natural killer cells.
  • IL-22 stimulates inflammatory responses like S100 and defensin.
  • IL-23 induces activation of the signal transducer and activator of STAT4.
  • IL-28 has a role in the immune defense against viruses.
  • IL-29 similar to IL-28.
  • IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.
  • IL-34 increases growth or survival of monocytes.
  • IL-36 acts on naïve CD4+ T cells.

3D structures of interleukin

Updated on 28-April-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Interleukin"
Personal tools