Isopenicillin N synthase
From Proteopedia
(Difference between revisions)
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**[[1bk0]] - AnIPNS + ACV – ''Aspergillus nidulans''<br /> | **[[1bk0]] - AnIPNS + ACV – ''Aspergillus nidulans''<br /> | ||
**[[2bjs]] - AnIPNS (mutant) + ACV<br /> | **[[2bjs]] - AnIPNS (mutant) + ACV<br /> | ||
| - | **[[1qiq]], [[1qjf]], [[1hb1]], [[1hb2]], [[1hb3]], [[1hb4]], [[1odm]], [[1odn]], [[1oc1]], [[1uzw]], [[1w03]], [[1w05]], [[2bu9]], [[1w3v]], [[1w3x]], [[2ivi]], [[2ivj]], [[2vau]], [[2vbb]], [[2vbd]], [[2vbp]], [[2vcm]], [[2ve1]], [[2wo7]], [[2y6f]], [[2y60]], [[2y86]] - AnIPNS + ACV derivative<br /> | + | **[[1qiq]], [[1qjf]], [[1hb1]], [[1hb2]], [[1hb3]], [[1hb4]], [[1odm]], [[1odn]], [[1oc1]], [[1uzw]], [[1w03]], [[1w05]], [[2bu9]], [[1w3v]], [[1w3x]], [[2ivi]], [[2ivj]], [[2vau]], [[2vbb]], [[2vbd]], [[2vbp]], [[2vcm]], [[2ve1]], [[2wo7]], [[2y6f]], [[2y60]], [[2y86]], [[4bb3]] - AnIPNS + ACV derivative<br /> |
**[[2jb4]] - AnIPNS + cyclobutanone analog<br /> | **[[2jb4]] - AnIPNS + cyclobutanone analog<br /> | ||
**[[1qje]] - AnIPNS + IPN + ACV<br /> | **[[1qje]] - AnIPNS + IPN + ACV<br /> | ||
**[[1blz]] - AnIPNS + NO + ACV<br /> | **[[1blz]] - AnIPNS + NO + ACV<br /> | ||
| - | **[[1obn]], [[1w04]], [[1w06]] - AnIPNS + hydroxylamine + ACV derivative | + | **[[1obn]], [[1w04]], [[1w06]] - AnIPNS + hydroxylamine + ACV derivative<br /> |
| + | **[[3zku]], [[3zky]], [[3zoi]], [[4bb3]] - IPNS + ACV derivative – ''Emericella nidulans''<br /> | ||
*Mn containing IPNS | *Mn containing IPNS | ||
Revision as of 08:58, 30 April 2015
Isopenicillin N synthase (IPNS) is an iron-dependent enzyme which catalyzes the formation of isopenicillin N (IPN) from the tripeptide aminoadipoyl-cysteine-valine (ACV). IPNS participates in the biosynthesis of penicillin and cephalosporin antibiotics. The active site of IPNS contains an Fe atom. The reaction involves the reduction of O2 molecule to H2O.
3D structures of isopenicillin N synthase
Updated on 30-April-2015
