Isopropylmalate dehydrogenase
From Proteopedia
(Difference between revisions)
| Line 37: | Line 37: | ||
**[[1wpw]] - IMDH + Mg – ''Sulfolobus tokodaii''<br /> | **[[1wpw]] - IMDH + Mg – ''Sulfolobus tokodaii''<br /> | ||
**[[2pkp]] - IMDH small subunit + Zn – ''Methanocaldococcus jannaschii''<br /> | **[[2pkp]] - IMDH small subunit + Zn – ''Methanocaldococcus jannaschii''<br /> | ||
| - | **[[4iwh]] - | + | **[[4iwh]] - BtIMDH + Mg – ''Burkholderia thailandensis''<br /> |
| + | **[[4xxv]] - BtIMDH + NAD<br /> | ||
*IMDH ternary complexes | *IMDH ternary complexes | ||
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**[[2y41]] - TtIMDH + 3IPM + Mn<br /> | **[[2y41]] - TtIMDH + 3IPM + Mn<br /> | ||
**[[4f7i]] - TtIMDH + Mg + 3IPM + NAD<br /> | **[[4f7i]] - TtIMDH + Mg + 3IPM + NAD<br /> | ||
| + | **[[4wuo]] - TtIMDH (mutant) + Mn + 3IPM + NAD<br /> | ||
**[[1a05]] – IMDH + 3IPM + Mg - ''Acidithiobacillus ferrooxidans''<br /> | **[[1a05]] – IMDH + 3IPM + Mg - ''Acidithiobacillus ferrooxidans''<br /> | ||
**[[3vkz]], [[3vl2]], [[3vl3]], [[3vl4]], [[3vl6]], [[3vl7]] - SoIMDH + 3IPM + Ca <br /> | **[[3vkz]], [[3vl2]], [[3vl3]], [[3vl4]], [[3vl6]], [[3vl7]] - SoIMDH + 3IPM + Ca <br /> | ||
Revision as of 09:51, 30 April 2015
Isopropylmalate dehydrogenase (IMDH) catalyzes the oxidative decarboxylation of 3-isopropylmalate (3IPM) to 2-oxo-4-methylvalerate. This reaction is a step in the biosynthesis of leucine in bacteria and fungi. IMDH uses NAD as a cofactor. IMDH is a bifunctional enzyme that catalyzes dehydrogenation and decarboxylation in the presence of NAD and a divalent cation.
3D structures of isopropylmalate dehydrogenase
Updated on 30-April-2015
