2vl5

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(New page: 200px {{Structure |PDB= 2vl5 |SIZE=350|CAPTION= <scene name='initialview01'>2vl5</scene>, resolution 2.10&Aring; |SITE= |LIGAND= |ACTIVITY= |GENE= }} '''STRU...)
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Revision as of 16:47, 20 March 2008

Image:2vl5.jpg


PDB ID 2vl5

Drag the structure with the mouse to rotate
, resolution 2.10Å
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF ANTI-COLLAGEN TYPE II FAB CIIC1


Overview

Monoclonal anti-collagen type II antibody CIIC1 is an arthritogenic autoantibody, which induces arthritis in mice. We crystallized and solved the structure of CIIC1 Fab molecule. Analysis of structure revealed an interaction between the CDR regions of one Fab to the CH1 domain of another Fab, which resembles an antibody-antigen interaction. ELISA experiments confirmed the cross-reactivity of both the full CIIC1 antibody and a single chain Fv fragment to other anti-collagen antibodies which are of different isotypes and epitope specificity. The rheumatoid factor like reactivity of CIIC1 antibody together with its collagen type II specificity may explain the pathogenicity of this antibody.

About this Structure

2VL5 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab: Structure to function analysis., Uysal H, Sehnert B, Nandakumar KS, Boiers U, Burkhardt H, Holmdahl R, Thunnissen MM, Mol Immunol. 2008 Apr;45(8):2196-204. Epub 2008 Feb 1. PMID:18241923

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