Janus kinase
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_3tjc| PDB=3tjc | SIZE=350| SCENE= |right|CAPTION=JAK2 complex with inhibitor thienopyridine [[3tjc]] }} | {{STRUCTURE_3tjc| PDB=3tjc | SIZE=350| SCENE= |right|CAPTION=JAK2 complex with inhibitor thienopyridine [[3tjc]] }} | ||
| - | '''Janus kinase''' (JAK) are nonreceptor tyrosine kinases which transduces cytokine-mediated signals via the JAK-STAT pathway. The JAK-STAT pathway transmits signals through the cell membrane to DNA promoters thus causing transcription. The name JAK is derived from Just Another Kinase. JAK proteins contain 2 phosphate-transfer domains, one with kinase activity using a phosphotyrosine (PTyr) and the other a pseudokinase domain which negatively regulates the kinase domain. JAK contains seven Janus homology domains named JH1-7. JAK family members are JAK1, JAK2, JAK3 and TYK2. JAK1 and TYK2 are involved in signaling by members of type I and type II cytokine receptors | + | '''Janus kinase''' (JAK) are nonreceptor tyrosine kinases which transduces cytokine-mediated signals via the JAK-STAT pathway. The JAK-STAT pathway transmits signals through the cell membrane to DNA promoters thus causing transcription. The name JAK is derived from Just Another Kinase. JAK proteins contain 2 phosphate-transfer domains, one with kinase activity using a phosphotyrosine (PTyr) and the other a pseudokinase domain which negatively regulates the kinase domain. JAK contains seven Janus homology domains named JH1-7. JAK family members are JAK1, JAK2, JAK3 and TYK2. For TYK2 see {{Tyrosine kinase]]. '''JAK1''' and TYK2 are involved in signaling by members of type I and type II cytokine receptors. '''JAK2''' is involved in signaling by members of the interferon receptors (type II cytokines). '''JAK3''' is predominantly active in immune cells. JAK3 is activated by cytokines whose receptors contain the common γ chain subunit (interleukin 2,4,7,9,15,21). TYK2 is a component of type I and type III interferon signaling pathways. |
== 3D Structures of Janus kinase == | == 3D Structures of Janus kinase == | ||
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*JAK1 | *JAK1 | ||
| - | **[[4e4l]], [[4e4n]], [[4e5w]], [[4ehz]], [[4ei4]], [[4fk6]], [[4i5c]], [[4k6z]] – hJAK1 kinase domain + PTyr + inhibitor - human<br /> | + | **[[4e4l]], [[4e4n]], [[4e5w]], [[4ehz]], [[4ei4]], [[4fk6]], [[4i5c]], [[4k6z]], [[3eyg]], [[3eyh]] – hJAK1 kinase domain + PTyr + inhibitor - human<br /> |
**[[4k77]] – hJAK1 JH1 domain + PTyr + inhibitor <br /> | **[[4k77]] – hJAK1 JH1 domain + PTyr + inhibitor <br /> | ||
**[[4l00]] – hJAK1 pseudokinase domain <br /> | **[[4l00]] – hJAK1 pseudokinase domain <br /> | ||
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**[[2b7a]], [[3fup]], [[4e6d]], [[4e6q]], [[4f08]] – hJAK2 kinase domain (mutant) + PTyr + inhibitor <br /> | **[[2b7a]], [[3fup]], [[4e6d]], [[4e6q]], [[4f08]] – hJAK2 kinase domain (mutant) + PTyr + inhibitor <br /> | ||
**[[3ugc]], [[4bbe]], [[4bbf]], [[3zmm]], [[2xa4]], [[4c61]], [[4c62]] – hJAK2 kinase domain (mutant) + inhibitor <br /> | **[[3ugc]], [[4bbe]], [[4bbf]], [[3zmm]], [[2xa4]], [[4c61]], [[4c62]] – hJAK2 kinase domain (mutant) + inhibitor <br /> | ||
| - | **[[3e62]], [[3e63]], [[3e64]], [[2w1i]], [[3io7]], [[3iok]], [[3kck]], [[3jy9]], [[3lpb]], [[3krr]], [[3q32]], [[3tjc]], [[3tjd]], [[3rvg]], [[4aqc]], [[4e4m]], [[4f09]], [[4hge]] – hJAK2 kinase domain + PTyr + inhibitor <br /> | + | **[[3e62]], [[3e63]], [[3e64]], [[2w1i]], [[3io7]], [[3iok]], [[3kck]], [[3jy9]], [[3lpb]], [[3krr]], [[3q32]], [[3tjc]], [[3tjd]], [[3rvg]], [[4aqc]], [[4e4m]], [[4f09]], [[4hge]], [[4d0w]], [[4d0x]], [[4d1s]], [[4p7e]], [[4aep]] – hJAK2 kinase domain + PTyr + inhibitor <br /> |
**[[4gl9]] – mJAK2 kinase domain + PTyr + inhibitor + suppressor of cytokine signaling 3 + interleukin 6 receptor subunit β - mouse<br /> | **[[4gl9]] – mJAK2 kinase domain + PTyr + inhibitor + suppressor of cytokine signaling 3 + interleukin 6 receptor subunit β - mouse<br /> | ||
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**[[3lxk]], [[3lxl]] – hJAK3 kinase domain (mutant) + PTyr + inhibitor <br /> | **[[3lxk]], [[3lxl]] – hJAK3 kinase domain (mutant) + PTyr + inhibitor <br /> | ||
**[[3pjc]] – hJAK3 kinase domain + inhibitor <br /> | **[[3pjc]] – hJAK3 kinase domain + inhibitor <br /> | ||
| - | **[[4hvd]], [[4hvg]], [[4hvh]], [[4hvi]], [[3zc6]], [[3zep]], [[4i6q]] – hJAK3 kinase domain (mutant) + inhibitor <br /> | + | **[[4hvd]], [[4hvg]], [[4hvh]], [[4hvi]], [[3zc6]], [[3zep]], [[4i6q]], [[4qps]], [[4rio]] – hJAK3 kinase domain (mutant) + inhibitor <br /> |
| - | *TYK2 kinase | + | *TYK2 see [[Tyrosine kinase]] |
| - | **[[3lxn]], [[3lxp]] – hTYK2 kinase domain (mutant) + PTyr + inhibitor<br /> | ||
| - | **[[3nyx]], [[3nz0]] – hTYK2 kinase domain (mutant) + inhibitor<br /> | ||
| - | **[[4e1z]], [[4e20]] – mTYK2 kinase domain (mutant) + inhibitor<br /> | ||
| - | |||
| - | *TYK2 pseudokinase domain | ||
| - | |||
| - | **[[3zon]] – hTYK2 pseudokinase domain + inhibitor <br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:15, 30 April 2015
Janus kinase (JAK) are nonreceptor tyrosine kinases which transduces cytokine-mediated signals via the JAK-STAT pathway. The JAK-STAT pathway transmits signals through the cell membrane to DNA promoters thus causing transcription. The name JAK is derived from Just Another Kinase. JAK proteins contain 2 phosphate-transfer domains, one with kinase activity using a phosphotyrosine (PTyr) and the other a pseudokinase domain which negatively regulates the kinase domain. JAK contains seven Janus homology domains named JH1-7. JAK family members are JAK1, JAK2, JAK3 and TYK2. For TYK2 see {{Tyrosine kinase]]. JAK1 and TYK2 are involved in signaling by members of type I and type II cytokine receptors. JAK2 is involved in signaling by members of the interferon receptors (type II cytokines). JAK3 is predominantly active in immune cells. JAK3 is activated by cytokines whose receptors contain the common γ chain subunit (interleukin 2,4,7,9,15,21). TYK2 is a component of type I and type III interferon signaling pathways.
3D Structures of Janus kinase
Updated on 30-April-2015
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
