2vo1

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(New page: 200px<br /><applet load="2vo1" size="350" color="white" frame="true" align="right" spinBox="true" caption="2vo1, resolution 2.80&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:2vo1.jpg|left|200px]]<br /><applet load="2vo1" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2vo1.jpg|left|200px]]
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caption="2vo1, resolution 2.80&Aring;" />
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'''CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE'''<br />
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{{Structure
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|PDB= 2vo1 |SIZE=350|CAPTION= <scene name='initialview01'>2vo1</scene>, resolution 2.80&Aring;
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|SITE= <scene name='pdbsite=AC1:Binding+Site+For+Residue+So4+A+1273'>AC1</scene>, <scene name='pdbsite=AC2:Binding+Site+For+Residue+So4+A+1274'>AC2</scene>, <scene name='pdbsite=AC3:Binding+Site+For+Residue+So4+A+1275'>AC3</scene>, <scene name='pdbsite=AC4:Binding+Site+For+Residue+So4+B+1273'>AC4</scene> and <scene name='pdbsite=AC5:Binding+Site+For+Residue+So4+B+1274'>AC5</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/CTP_synthase CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2]
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2VO1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/CTP_synthase CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] Known structural/functional Sites: <scene name='pdbsite=AC1:Binding+Site+For+Residue+So4+A+1273'>AC1</scene>, <scene name='pdbsite=AC2:Binding+Site+For+Residue+So4+A+1274'>AC2</scene>, <scene name='pdbsite=AC3:Binding+Site+For+Residue+So4+A+1275'>AC3</scene>, <scene name='pdbsite=AC4:Binding+Site+For+Residue+So4+B+1273'>AC4</scene> and <scene name='pdbsite=AC5:Binding+Site+For+Residue+So4+B+1274'>AC5</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VO1 OCA].
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2VO1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 2C5M. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VO1 OCA].
==Reference==
==Reference==
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Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy., Kursula P, Flodin S, Ehn M, Hammarstrom M, Schuler H, Nordlund P, Stenmark P, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):613-7. Epub 2006 Jun 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16820675 16820675]
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Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy., Kursula P, Flodin S, Ehn M, Hammarstrom M, Schuler H, Nordlund P, Stenmark P, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):613-7. Epub 2006 Jun 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16820675 16820675]
[[Category: CTP synthase]]
[[Category: CTP synthase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: utp]]
[[Category: utp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Mar 14 09:36:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:47:52 2008''

Revision as of 16:47, 20 March 2008

Image:2vo1.jpg


PDB ID 2vo1

Drag the structure with the mouse to rotate
, resolution 2.80Å
Sites: , , , and
Ligands:
Activity: CTP synthase, with EC number 6.3.4.2
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE


Overview

Cytidine triphosphate synthetase (CTPS) is a key enzyme in nucleic acid and phospholipid biosynthesis and its activity is increased in certain human cancers, making it a promising drug target. The crystal structure of the synthetase domain of human CTPS, which represents the first structure of a CTPS from an eukaryote, has been determined. The structure is homotetrameric and each active site is formed by three different subunits. Sulfate ions bound to the active sites indicate the positions of phosphate-binding sites for the substrates ATP and UTP and the feedback inhibitor CTP. Together with earlier structures of bacterial CTPS, the human CTPS structure provides an extended understanding of the structure-function relationship of CTPS-family members. The structure also serves as a basis for structure-based design of anti-proliferative inhibitors.

About this Structure

2VO1 is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2C5M. Full crystallographic information is available from OCA.

Reference

Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy., Kursula P, Flodin S, Ehn M, Hammarstrom M, Schuler H, Nordlund P, Stenmark P, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):613-7. Epub 2006 Jun 10. PMID:16820675

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