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2n0x

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'''Unreleased structure'''
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==Three dimensional structure of EPI-X4, a human albumin-derived peptide that regulates innate immunity through the CXCR4/CXCL12 chemotactic axis and antagonizes HIV-1 entry==
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<StructureSection load='2n0x' size='340' side='right' caption='[[2n0x]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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The entry 2n0x is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n0x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N0X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N0X FirstGlance]. <br>
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Authors: Perez-Castells, J., Canales, A., Jimenez-Barbero, J., Gimenez-Gallego, G.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n0x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2n0x RCSB], [http://www.ebi.ac.uk/pdbsum/2n0x PDBsum]</span></td></tr>
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</table>
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Description: Three dimensional structure of EPI-X4, a human albumin-derived peptide that regulates innate immunity through the CXCR4/CXCL12 chemotactic axis and antagonizes HIV-1 entry
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== Disease ==
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[[Category: Unreleased Structures]]
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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[[Category: Jimenez-Barbero, J]]
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== Function ==
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[[Category: Gimenez-Gallego, G]]
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Canales, A]]
[[Category: Canales, A]]
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[[Category: Gimenez-Gallego, G]]
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[[Category: Jimenez-Barbero, J]]
[[Category: Perez-Castells, J]]
[[Category: Perez-Castells, J]]
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[[Category: Antagonist]]
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[[Category: Inhibitor peptide]]
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[[Category: Peptide binding protein]]

Revision as of 11:31, 30 April 2015

Three dimensional structure of EPI-X4, a human albumin-derived peptide that regulates innate immunity through the CXCR4/CXCL12 chemotactic axis and antagonizes HIV-1 entry

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