4q6s
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36== |
| - | + | <StructureSection load='4q6s' size='340' side='right' caption='[[4q6s]], [[Resolution|resolution]] 1.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jof|4jof]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [http://www.ebi.ac.uk/pdbsum/4q6s PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Amacher, J | + | == Disease == |
| - | [[Category: Madden, D | + | [[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Amacher, J F]] | ||
| + | [[Category: Madden, D R]] | ||
| + | [[Category: Pdz-peptide complex]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 11:33, 30 April 2015
CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36
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