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4xxo
From Proteopedia
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| - | ''' | + | ==Crystal Structure of Human APOBEC3A== |
| - | + | <StructureSection load='4xxo' size='340' side='right' caption='[[4xxo]], [[Resolution|resolution]] 2.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4xxo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XXO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xxo RCSB], [http://www.ebi.ac.uk/pdbsum/4xxo PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | [[Category: Schiffer, C | + | [[http://www.uniprot.org/uniprot/ABC3A_HUMAN ABC3A_HUMAN]] DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<ref>PMID:10469298</ref> <ref>PMID:12859895</ref> <ref>PMID:16527742</ref> <ref>PMID:19461882</ref> <ref>PMID:20615867</ref> <ref>PMID:20062055</ref> <ref>PMID:21496894</ref> <ref>PMID:21460793</ref> <ref>PMID:21123384</ref> <ref>PMID:21368204</ref> <ref>PMID:22896697</ref> <ref>PMID:22457529</ref> |
| - | [[Category: Shandilya, S | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bohn, M F]] | ||
| + | [[Category: Schiffer, C A]] | ||
| + | [[Category: Shandilya, S M.D]] | ||
| + | [[Category: Apobec]] | ||
| + | [[Category: Apobec3]] | ||
| + | [[Category: Apolipoprotein b mrna editing polypeptide-like 3]] | ||
| + | [[Category: Deaminase]] | ||
| + | [[Category: Deamination]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 11:37, 30 April 2015
Crystal Structure of Human APOBEC3A
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