5aie
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Not4 ring domain in complex Ubc4== |
| - | + | <StructureSection load='5aie' size='340' side='right' caption='[[5aie]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5aie]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AIE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5aie RCSB], [http://www.ebi.ac.uk/pdbsum/5aie PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NOT4_YEAST NOT4_YEAST]] Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.<ref>PMID:9463387</ref> [[http://www.uniprot.org/uniprot/UBC4_YEAST UBC4_YEAST]] Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Mediates ubiquitination of PEX5.<ref>PMID:17550898</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ubiquitin--protein ligase]] | ||
[[Category: Basquin, J]] | [[Category: Basquin, J]] | ||
[[Category: Bhaskar, V]] | [[Category: Bhaskar, V]] | ||
[[Category: Conti, E]] | [[Category: Conti, E]] | ||
| + | [[Category: E2-e3 ligase]] | ||
| + | [[Category: Ligase]] | ||
| + | [[Category: Not4 ring domain]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Ubc4]] | ||
Revision as of 11:40, 30 April 2015
Not4 ring domain in complex Ubc4
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