5ajd

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'''Unreleased structure'''
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==Not1 C-terminal domain in complex with Not4==
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<StructureSection load='5ajd' size='340' side='right' caption='[[5ajd]], [[Resolution|resolution]] 3.62&Aring;' scene=''>
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The entry 5ajd is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ajd]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJD FirstGlance]. <br>
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Authors: Bhaskar, V., Basquin, J., Conti, E.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ajd RCSB], [http://www.ebi.ac.uk/pdbsum/5ajd PDBsum]</span></td></tr>
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</table>
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Description: Not1 C-terminal domain in complex with Not4
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== Function ==
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[[Category: Unreleased Structures]]
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[[http://www.uniprot.org/uniprot/NOT4_YEAST NOT4_YEAST]] Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.<ref>PMID:9463387</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Basquin, J]]
[[Category: Basquin, J]]
[[Category: Bhaskar, V]]
[[Category: Bhaskar, V]]
[[Category: Conti, E]]
[[Category: Conti, E]]
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[[Category: Ccr4-not]]
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[[Category: Not1]]
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[[Category: Not4]]
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[[Category: Transcription]]

Revision as of 11:40, 30 April 2015

Not1 C-terminal domain in complex with Not4

5ajd, resolution 3.62Å

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