Lysine-specific histone demethylase
From Proteopedia
(Difference between revisions)
| Line 13: | Line 13: | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *lysine-specific histone demethylase | + | *lysine-specific histone demethylase |
**[[2com]], [[2l3d]] - hLSD1 SWIRM domain – human – NMR<br /> | **[[2com]], [[2l3d]] - hLSD1 SWIRM domain – human – NMR<br /> | ||
**[[2h94]], [[2dw4]], [[2z3y]], [[2z5u]], [[4fwe]], [[4fwj]], [[4gu1]] – hLSD1<br /> | **[[2h94]], [[2dw4]], [[2z3y]], [[2z5u]], [[4fwe]], [[4fwj]], [[4gu1]] – hLSD1<br /> | ||
**[[2hko]] – hLSD1 (mutant)<br /> | **[[2hko]] – hLSD1 (mutant)<br /> | ||
| + | **[[2xdp]] – hLSD 4C tudor domain <br /> | ||
| + | **[[2xml]], [[4xdp]] – hLSD 4C catalytic domain <br /> | ||
| + | **[[4xdo]] – hLSD 4C catalytic domain + oxalylglycine <br /> | ||
| + | **[[2ma5]] – hLSD 5B zinc finger domain 3 - NMR<br /> | ||
| + | **[[2mny]] – hLSD 5B zinc finger domain 1 - NMR<br /> | ||
**[[2ejr]], [[3abt]], [[3abu]] – hLSD1 + tranylcypromine derivative<br /> | **[[2ejr]], [[3abt]], [[3abu]] – hLSD1 + tranylcypromine derivative<br /> | ||
| + | **[[4gut]], [[4guu]] – hLSD1 + oxidoreductase<br /> | ||
| + | |||
| + | *LSD complex with histone H3 peptide | ||
| + | |||
| + | **[[4v2v]] – hLSD 4C catalytic domain + histone 3.1 peptide <br /> | ||
| + | **[[2mnz]] – hLSD 5B zinc finger domain 1 + histone 3 peptide - NMR<br /> | ||
**[[4fwf]] – hLSD1 + histone 3.1 peptide<br /> | **[[4fwf]] – hLSD1 + histone 3.1 peptide<br /> | ||
**[[4gu0]] – hLSD1 + histone 3.3 peptide<br /> | **[[4gu0]] – hLSD1 + histone 3.3 peptide<br /> | ||
**[[4gur]], [[4gus]], [[4hsu]] – hLSD1 + histone 3.3 peptide + oxidoreductase<br /> | **[[4gur]], [[4gus]], [[4hsu]] – hLSD1 + histone 3.3 peptide + oxidoreductase<br /> | ||
| - | **[[4gut]], [[4guu]] – hLSD1 + oxidoreductase<br /> | ||
*LSD1 complex with CoREST | *LSD1 complex with CoREST | ||
| Line 30: | Line 40: | ||
**[[2x0l]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 1-16<br /> | **[[2x0l]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 1-16<br /> | ||
**[[2xaf]], [[2xag]], [[2xah]], [[2xaj]], [[2xaq]], [[2xas]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + tranylcypromine derivative<br /> | **[[2xaf]], [[2xag]], [[2xah]], [[2xaj]], [[2xaq]], [[2xas]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + tranylcypromine derivative<br /> | ||
| - | **[[2y48]] - | + | **[[2y48]] - hLSD1A residues 123-852 + CoREST SANT1 and SANT2 domains + zinc finger protein SNAIL N terminal<br /> |
| - | **[[3zms]], [[3zmt]], [[3zmu]], [[3zmv]], [[3zmz]], [[3zn0]], [[3zn1]] - | + | **[[3zms]], [[3zmt]], [[3zmu]], [[3zmv]], [[3zmz]], [[3zn0]], [[3zn1]] - hLSD1A residues 123-852 + CoREST SANT1 and SANT2 domains + zinc finger protein IA-1 peptide <br /> |
| + | **[[4bay]] - hLSD1A residues 192-876 + CoREST residues 308-440 <br /> | ||
| + | **[[4kum]] - hLSD1A SWIRM + FAD domains + CoREST residues 289-485 <br /> | ||
| + | **[[4czz]] - hLSD1A + CoREST <br /> | ||
| + | **[[4uv8]], [[4uv9]], [[4uva]], [[4uvb]], [[4ubc]] - hLSD1A + CoREST + irreversible inhibitor<br /> | ||
| + | **[[4uxn]] - hLSD1A + CoREST + pyrrolydine inhibitor<br /> | ||
| + | |||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:32, 4 May 2015
Lysine-specific histone demethylase 1 (LSD1) is a flavin-dependent oxidase that catalyzes the removal of methyl groups from mono- and dimethylated lysine 4 of histone H3. LSD1 is a nuclear homolog of amine oxidase. It functions as histone demethylase and transcriptional corepressor. LSD1 demethylation occurs via a reaction which produces formaldehyde. LSD1 is a component of transcriptional corepressor complex which also contains CoREST (corepressor of element-1-silencing transcription factor).
3D structures of lysine-specific histone demethylase 1
Updated on 04-May-2015
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
